Male-specific lethal 3 homolog (MSL3) Recombinant Protein | MSL3 recombinant protein

Recombinant Human Male-specific lethal 3 homolog (MSL3)

Cat. Num. AAA1279846

• Gene Names: MSL3; MSL3L1
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Male-specific lethal 3 homolog (MSL3); Recombinant Human Male-specific lethal 3 homolog (MSL3); MSL3 recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Positions: 1-521, Full length protein
• Sequence: MSASEGMKFKFHSGEKVLCFEPDPTKARVLYDAKIVDVIVGKDEKGRKIPEYLIHFNGWNRSWDRWAAEDHVLRDTDENRRLQRKLARKAVARLRSTGRKKKRCRLPGVDSVLKGLPTEEKDENDENSLSSSSDCSENKDEEISEESDIEEKTEVKEEPELQTRREMEERTITIEIPEVLKKQLEDDCYYINRRKRLVKLPCQTNIITILESYVKHFAINAAFSANERPRHHHVMPHANMNVHYIPAEKNVDLCKEMVDGLRITFDYTLPLVLLYPYEQAQYKKVTSSKFFLPIKESATSTNRSQEELSPSPPLLNPSTPQSTESQPTTGEPATPKRRKAEPEALQSLRRSTRHSANCDRLSESSASPQPKRRQQDTSASMPKLFLHLEKKTPVHSRSSSPIPLTPSKEGSAVFAGFEGRRTNEINEVLSWKLVPDNYPPGDQPPPPSYIYGAQHLLRLFVKLPEILGKMSFSEKNLKALLKHFDLFLRFLAEYHDDFFPESAYVAACEAHYSTKNPRAIY
• Sequence Length: 521

• Species: Human
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

Related Product Information for MSL3 recombinant protein

This gene encodes a nuclear protein and has similarity to drosophila male-specific lethal-3 gene. The drosophila protein plays a critical role in a dosage-compensation pathway, which equalizes X-linked gene expression in males and females. Thus this encoded protein is thought to play a similar function in chromatin remodeling and transcriptional regulation. This gene has been found to undergo X inactivation. There are four alternatively spliced transcript variants of this gene encoding different isoforms.

NCBI and Uniprot Product Information

• NCBI GI #: 300796021
• NCBI GeneID: 10943
• NCBI Accession #: NP_001180199.1
• NCBI GenBank Nucleotide #: NM_001193270.2
• UniProt Accession #: Q8N5Y2; Q9UG70; Q9Y5Z8; A6NCU2; A6NHW8; A8K165; B4DUV8; B7Z227
• Molecular Weight: 42,725 Da
• NCBI Official Full Name: male-specific lethal 3 homolog isoform e
• NCBI Official Synonym Full Names: MSL complex subunit 3
• NCBI Official Symbol: MSL3
• NCBI Official Synonym Symbols: MSL3L1
• NCBI Protein Information: male-specific lethal 3 homolog
• UniProt Protein Name: Male-specific lethal 3 homolog
• Protein Family: Male-specific lethal
• UniProt Gene Name: MSL3
• UniProt Synonym Gene Names: MSL3L1; MSL3-like 1

NCBI Description

This gene encodes a nuclear protein that is similar to the product of the Drosophila male-specific lethal-3 gene. The Drosophila protein plays a critical role in a dosage-compensation pathway, which equalizes X-linked gene expression in males and females. Thus, the human protein is thought to play a similar function in chromatin remodeling and transcriptional regulation, and it has been found as part of a complex that is responsible for histone H4 lysine-16 acetylation. This gene can undergo X inactivation. Alternative splicing results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 2, 7 and 8. [provided by RefSeq, Jul 2010]

Uniprot Description

May be involved in chromatin remodeling and transcriptional regulation. May have a role in X inactivation. Component of the MSL complex which is responsible for the majority of histone H4 acetylation at 'Lys-16' which is implicated in the formation of higher-order chromatin structure. Specifically recognizes histone H4 monomethylated at 'Lys-20' (H4K20Me1) in a DNA-dependent manner and is proposed to be involved in chromosomal targeting of the MSL complex.