C1orf33/MRTO4 Recombinant Protein | MRTO4 recombinant protein

C1orf33/MRTO4 Protein, Human, Recombinant (His Tag)

Cat. Num. AAA8121755

• Gene Names: MRTO4; MRT4; C1orf33; dJ657E11.4
• Purity: >95% as determined by SDS-PAGE
• Synonyms: C1orf33/MRTO4; C1orf33/MRTO4 Protein; Human; Recombinant (His Tag); Human MRTO4/MRT4 Protein (His Tag); C1orf33 Protein; dJ657E11.4 Protein; MRT4 Protein; MRT4 homolog; ribosome maturation factor; MRTO4 recombinant protein

• Host: E Coli
• Purity/Purification: >95% as determined by SDS-PAGE
• Form/Format: Lyophilized from sterile 20mM Tris, 500mM NaCl, 10% glycerol, pH8.0. Normally 5%-8% trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Please refer to the specific buffer information in the hard copy of CoA.
• Sequence: Met1-Asp239

• Species: Human
• Predicted N Terminal: His
• Tag: N-His
• Protein Construction: A DNA sequence encoding the human MRTO4 (Q9UKD2)(Met1-Asp239) was expressed with a polyhistidine tag at the N-terminus.
• Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
• Preparation and Storage: Samples are stable for up to twelve months from date of receipt at -20 degree C to -80 degree C. Store it under sterile conditions at -20 degree C to -80 degree C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.; In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. Bulk packages of recombinant proteins are provided as frozen liquid.; They are shipped out with blue ice.

SDS-Page

Related Product Information for MRTO4 recombinant protein

Background: MRTO4 (MRT4 Homolog, Ribosome Maturation Factor) is a Protein Coding gene. MRTO4, also known as MRT4, belongs to the universal ribosomal protein uL10 family. This gene encodes a protein sharing a low level of sequence similarity with ribosomal protein P0. MRTO4 is a nuclear paralog of the ribosomal protein P0, it binds pre-60S subunits at an early stage of assembly in the nucleolus, and is replaced by P0 in cytoplasmic pre-60S subunits and mature 80S ribosomes. The precise function of MRTO4 is currently unknown. It appears to be involved in mRNA turnover and ribosome assembly. MRTO4 is widely expressed in the appendix, lymph node, and other tissues. Diseases associated with MRTO4 include Bacterial Conjunctivitis and Robinow Syndrome, Autosomal Dominant 1.

References

Zhao J. et al., 2011, J Proteomics. 75 (2): 588-602. Havugimana PC. et al., 2012, Cell. 150 (5): 1068-81. Wu Z. et al., 2012, PLoS One. 7 (8): e43997. Michalec B. et al., 2010, Int J Biochem Cell Biol. 42 (5): 736-48.

NCBI and Uniprot Product Information

• NCBI GI #: 118572609
• NCBI GeneID: 51154
• NCBI Accession #: NP_057267.2
• NCBI GenBank Nucleotide #: NM_016183
• UniProt Accession #: Q9UKD2; Q5TG55; Q96SS6; Q9BPV9; B3KNB3
• Molecular Weight: 27,560 Da
• NCBI Official Full Name: Homo sapiens mRNA turnover 4 homolog (S. cerevisiae) (MRTO4), mRNA
• NCBI Official Synonym Full Names: mRNA turnover 4 homolog (S. cerevisiae)
• NCBI Official Symbol: MRTO4
• NCBI Official Synonym Symbols: MRT4; C1orf33; dJ657E11.4
• NCBI Protein Information: mRNA turnover protein 4 homolog; 60S acidic ribosomal protein PO; MRT4, mRNA turnover 4, homolog; ribosome assembly factor MRTO4
• UniProt Protein Name: mRNA turnover protein 4 homolog
• Protein Family: mRNA turnover protein
• UniProt Gene Name: MRTO4
• UniProt Entry Name: MRT4_HUMAN

NCBI Description

This gene encodes a protein sharing a low level of sequence similarity with ribosomal protein P0. While the precise function of the encoded protein is currently unknown, it appears to be involved in mRNA turnover and ribosome assembly. [provided by RefSeq, Jul 2008]

Uniprot Description

MRTO4: Involved in mRNA turnover and ribosome assembly. Belongs to the ribosomal protein L10P family.

Protein type: Nucleolus; RNA-binding

Chromosomal Location of Human Ortholog: 1p36.13

Cellular Component: nucleoplasm; nuclear membrane; cytoplasm; nucleolus; nucleus

Biological Process: ribosome biogenesis and assembly