Uniprot Description
S-adenosyl-L-methionine-dependent pseudouridine N1-methyltransferase that methylates the pseudouridine corresponding to position 1189 (Psi1189) in S.cerevisiae 18S rRNA. Involved the biosynthesis of the hypermodified N1-methyl-N3-(3-amino-3-carboxypropyl) pseudouridine (m1acp3-Psi) conserved in eukaryotic 18S rRNA. Has also an essential role in 40S ribosomal subunit biogenesis independent on its methyltransferase activity, facilitating the incorporation of ribosomal protein S19 during the formation of pre-ribosomes (). Essential for cell growth. It also has a key role in promoting the mating function (PubMed:9133664).
Product Notes
The mra1 mra1 (Catalog #
AAA1359016) is a Recombinant Protein produced from E Coli or Yeast or Baculovirus or Mammalian Cell and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 1-359, Full length. The amino acid sequence is listed below: MPTYSKRKSR GSLEVSEKTN QPKFIKRSQS SETITSGETA SELMQDEKEQ SNGAVGSIED EELQRLRENQ ASVEALSKKP ESIDRELGVE ALEIDNVVKS DEEKEDPNGA SSKTVKARPL PAGSVHRVTT HMAPIPARSI GSHDTTTQRL IVVLDQACLE IYKVGKAKDA KYQLLNCDDH QGILKKLNRN IAQARPDITH QCLLTLLDSP LNKAGRLQVY IHTAKKVLIE VNPSVRIPRT FKRFSGLMVQ LLHKLSIRSV NGNEKLLKVI KNPVTDYLPP NCRKATLSFD APTVPPRKYL ETLQPNQSVC IAIGAMAHGP DDFSDGWVDE KISISDYPLS ASIACSKFLH SMEDFLGIV.
It is sometimes possible for the material contained within the vial of
"Probable ribosomal RNA small subunit methyltransferase mra1 (mra1), Recombinant Protein" to become dispersed throughout the inside of
the vial, particularly around the seal of said vial, during shipment and storage. We always
suggest centrifuging these vials
to consolidate all of the liquid away from the lid and to the bottom of the vial prior to
opening. Please be advised that
certain products may require dry ice for shipping and that, if this is the case, an
additional dry ice fee may also be
required.
Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are
absolutely not suitable for use in any
sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a
product from AAA Biotech, you
are explicitly certifying that said products will be properly tested and used in line with
industry standard. AAA Biotech
and its authorized distribution partners reserve the right to refuse to fulfill any order if
we have any indication that a
purchaser may be intending to use a product outside of our accepted criteria.
Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech
cannot be held
responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any
aspect of this datasheet at
any time and without notice. It is the responsibility of the customer to inform AAA Biotech
of any product performance
issues observed or experienced within 30 days of receipt of said product. To see additional
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