TTDN1 Blocking Peptide | MPLKIP blocking peptide

TTDN1 Antibody (C-term) Blocking Peptide

• Gene Names: MPLKIP; ABHS; TTD4; ORF20; C7orf11
• Synonyms: TTDN1; TTDN1 Antibody (C-term) Blocking Peptide; M-phase-specific PLK1-interacting protein; TTD non-photosensitive 1 protein; MPLKIP; C7orf11; MPLKIP blocking peptide

• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 179

• Cellular Location: Nucleus. Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note: The subcellular location is regulated during cell cycle. During interphase located in the nucleus. During mitosis located at the centrosome and dispersed in the cytoplasm. During telophase located in the midbody. Colocalizes with PLK1 at the centrosome in M phase
• Tissue Location: Expressed at highest levels in liver and kidney; intermediate expression in skeletal muscle, pancreas, heart and placenta; low expression in brain and lung. Expressed in epidermis and hair follicles.
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for MPLKIP blocking peptide

May play a role in maintenance of cell cycle integrity by regulating mitosis or cytokinesis.

NCBI and Uniprot Product Information

• NCBI GI #: 71153365
• NCBI GeneID: 136647
• UniProt Accession #: Q8TAP9
• Molecular Weight: 19,147 Da
• NCBI Official Full Name: M-phase-specific PLK1-interacting protein
• NCBI Official Synonym Full Names: M-phase specific PLK1 interacting protein
• NCBI Official Symbol: MPLKIP
• NCBI Official Synonym Symbols: ABHS; TTD4; ORF20; C7orf11
• NCBI Protein Information: M-phase-specific PLK1-interacting protein
• UniProt Protein Name: M-phase-specific PLK1-interacting protein
• Protein Family: M-phase-specific PLK1-interacting protein
• UniProt Gene Name: MPLKIP
• UniProt Synonym Gene Names: C7orf11; TTDN1
• UniProt Entry Name: MPLKI_HUMAN

NCBI Description

The protein encoded by this gene localizes to the centrosome during mitosis and to the midbody during cytokinesis. The protein is phosphorylated by cyclin-dependent kinase 1 during mitosis and subsequently interacts with polo-like kinase 1. The protein is thought to function in regulating mitosis and cytokinesis. Mutations in this gene result in nonphotosensitive trichothiodystrophy. [provided by RefSeq, Nov 2009]

Uniprot Description

TTDN1: May play a role in maintenance of cell cycle integrity by regulating mitosis or cytokinesis. Defects in MPLKIP are a cause of trichothiodystrophy non- photosensitive type 1 (TTDN1); also known as Amish brittle hair brain syndrome (ABHS), hair-brain syndrome and BIDS syndrome. TTDN1 is an autosomal recessive disorder characterized by short stature, intellectual impairment, sulfur-deficient brittle hair and decreased male fertility but not cutaneous photosensitivity.

Protein type: Cell cycle regulation

Chromosomal Location of Human Ortholog: 7p14.1

Cellular Component: centrosome; cytoplasm; Golgi apparatus; midbody; nucleoplasm; nucleus

Molecular Function: protein binding

Disease: Trichothiodystrophy, Nonphotosensitive 1