Western Blot (WB)
(Western blotting analysis (non-reducing conditions) of Lyn using anti-Lyn (LYN-01).Lane 1: negative controlLane 2: RBL rat basophilic leukemia cell lineLane 3: JURKAT human peripheral blood T cell leukemia cell lineLane 4: A-431 human epidermoid carcinoma cell lineLane 5: U-937 human histiocytic lymphoma cell line)
Mouse LYN Antibody | anti-LYN antibody
Anti-LYN Purified
Gene Names
LYN; JTK8; p53Lyn; p56Lyn
Reactivity
Rat, Human, Mouse
Applications
Immunoprecipitation, Western Blot, Immunocytochemistry
Purity
Purified by Protein-A Affinity Chromatography
Synonyms
LYN; Anti-LYN Purified; LYN proto-oncogene; Src family tyrosine kinase; JTK8; p56Lyn; p53Lyn; anti-LYN antibody
Host
Mouse
Reactivity
Rat, Human, Mouse
Isotype
IgG1
Clone Number
LYN-01
Specificity
The antibody LYN-01 reacts with Lyn (p56/p53), a non-receptor Src-family tyrosine kinase expressed in hematopoietic tissues (intracellular antigen).
Purity/Purification
Purified by Protein-A Affinity Chromatography
Form/Format
Phosphate buffered saline (PBS) solution with 15 mM sodium azide
Concentration
1 mg/ml (varies by lot)
Sequence Length
491
Applicable Applications for anti-LYN antibody
Immunoprecipitation, Western Blot (WB), Immunocytochemistry (ICC)
Immunogen
Bacterially expressed recombinant fragment of human Lyn (aa 8 - 238).
Preparation and Storage
Store at 2-8 degree C.
Western Blot (WB)
(Western blotting analysis (non-reducing conditions) of Lyn using anti-Lyn (LYN-01).Lane 1: negative controlLane 2: RBL rat basophilic leukemia cell lineLane 3: JURKAT human peripheral blood T cell leukemia cell lineLane 4: A-431 human epidermoid carcinoma cell lineLane 5: U-937 human histiocytic lymphoma cell line)
Western Blot (WB)
(Western blotting analysis (non-reducing conditions) of Lyn using anti-Lyn (LYN-01).Lane 1: negative controlLane 2: RBL rat basophilic leukemia cell lineLane 3: JURKAT human peripheral blood T cell leukemia cell lineLane 4: A-431 human epidermoid carcinoma cell lineLane 5: U-937 human histiocytic lymphoma cell line)
Related Product Information for anti-LYN antibody
Lyn is a Src-family protein tyrosine kinase that is predominantly expressed in hematopoietic cells. It is associated with a number of cell surface receptors including the B cell antigen receptor (BCR) and Fc receptors. Upon their triggering, Lyn phosphorylates subunits of these receptors in a cholesterol-dependent manner, utilizing the plasma membrane lipid raft system. The phosphorylated intracellular domains of the receptors are accessible for cytoplasmic Syk tyrosine kinase, which is activated by Lyn-mediated phosphorylation and which transduces the signal to downstream adaptors. Lyn is abnormally distributed in acute myeloid leukemia cells and seems to be a novel pharmacologic target of this disease.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
NCBI Official Full Name
tyrosine-protein kinase Lyn isoform B
NCBI Official Synonym Full Names
LYN proto-oncogene, Src family tyrosine kinase
NCBI Official Symbol
LYN
NCBI Official Synonym Symbols
JTK8; p53Lyn; p56Lyn
NCBI Protein Information
tyrosine-protein kinase Lyn
UniProt Protein Name
Tyrosine-protein kinase Lyn
Protein Family
UniProt Gene Name
LYN
UniProt Synonym Gene Names
JTK8
UniProt Entry Name
LYN_HUMAN
NCBI Description
This gene encodes a tyrosine protein kinase, which maybe involved in the regulation of mast cell degranulation, and erythroid differentiation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2011]
Research Articles on LYN
Similar Products
Product Notes
The LYN lyn (Catalog #AAA1800923) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The Anti-LYN Purified reacts with Rat, Human, Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's LYN can be used in a range of immunoassay formats including, but not limited to, Immunoprecipitation, Western Blot (WB), Immunocytochemistry (ICC). Researchers should empirically determine the suitability of the LYN lyn for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "LYN, Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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