Western Blot (WB)
(Western blot analysis of extracts of THP-1 cell lines, using TPH1 antibody.)
Rabbit TPH1 Polyclonal Antibody | anti-TPH1 antibody
TPH1 antibody
Gene Names
TPH1; TPRH; TRPH
Reactivity
Human, Mouse, Rat
Applications
Western Blot
Purity
Antibodies were purified by affinity purification using immunogen.
Synonyms
TPH1; Polyclonal Antibody; TPH1 antibody; MGC119994; TPRH; TRPH; Tryptophan 5-hydroxylase 1; anti-TPH1 antibody
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Specificity
The antibody detects endogenous level of total TPH1 antibody.
Purity/Purification
Antibodies were purified by affinity purification using immunogen.
Form/Format
Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration
1.0 mg/ml (varies by lot)
Sequence Length
444
Applicable Applications for anti-TPH1 antibody
Western Blot (WB)
Application Notes
Western blotting: 1:500 - 1:2000
Immunogen Type
Recombinant Protein
Immunogen Description
Recombinant protein of human TPH1.
Target Name
TPH1
Preparation and Storage
Store at -20 degree C
Western Blot (WB)
(Western blot analysis of extracts of THP-1 cell lines, using TPH1 antibody.)
Western Blot (WB)
(Western blot analysis of extracts of THP-1 cell lines, using TPH1 antibody.)
Related Product Information for anti-TPH1 antibody
Tryptophan hydroxylase (TPH) is the rate-limiting enzyme in the biosynthesis of serotonin (1) by converting tryptophan to 5-hydroxy-L-tryptophan (2). Two isoforms of TPH exist: TPH-1 is mainly expressed in the periphery, whereas the expression of TPH-2 is restricted to neuronal cells and the central nervous system (3). Most of the serotonin found throughout the body is synthesized by TPH-1 in enterochromaffin cells of the gastrointestinal tract. Targeted disruption of the tph1 gene results in low levels of circulating and tissue serotonin (4).
Product Categories/Family for anti-TPH1 antibody
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
53,394 Da
NCBI Official Full Name
tryptophan 5-hydroxylase 1
NCBI Official Synonym Full Names
tryptophan hydroxylase 1
NCBI Official Symbol
TPH1
NCBI Official Synonym Symbols
TPRH; TRPH
NCBI Protein Information
tryptophan 5-hydroxylase 1
UniProt Protein Name
Tryptophan 5-hydroxylase 1
Protein Family
UniProt Gene Name
TPH1
UniProt Synonym Gene Names
TPH; TPRH; TRPH
UniProt Entry Name
TPH1_HUMAN
NCBI Description
This gene encodes a member of the aromatic amino acid hydroxylase family. The encoded protein catalyzes the first and rate limiting step in the biosynthesis of serotonin, an important hormone and neurotransmitter. Mutations in this gene have been associated with an elevated risk for a variety of diseases and disorders, including schizophrenia, somatic anxiety, anger-related traits, bipolar disorder, suicidal behavior, addictions, and others.[provided by RefSeq, Apr 2009]
Research Articles on TPH1
Similar Products
Product Notes
The TPH1 tph1 (Catalog #AAA9406787) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The TPH1 antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's TPH1 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Western blotting: 1:500 - 1:2000. Researchers should empirically determine the suitability of the TPH1 tph1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "TPH1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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