Mouse anti-Human, Mouse ApoO Antibody | anti-ApoO antibody

ApoO Antibody

Cat. Num. AAA850630

• Gene Names: APOO; MIC26; Mic23; My025; FAM121B
• Reactivity: Human, Mouse
• Applications: Western Blot, Immunohistochemistry, ELISA
• Synonyms: ApoO; ApoO Antibody; MYO25; FAM121B; MGC4825; anti-ApoO antibody

• Host: Mouse
• Reactivity: Human, Mouse
• Isotype: IgG1
• Clone Number: 2F1
• Form/Format: Ascitic fluid containing 0.03% sodium azide.
• Sequence Length: 198

• Applicable Applications for anti-ApoO antibody: Western Blot (WB), Immunohistochemistry (IHC), ELISA (EIA)
• Application Notes: WB: 1:500-1:2000; IHC: 1:200-1:1000; ELISA: 1:10000
• Immunogen: Purified recombinant fragment of ApoO expressed in E. Coli.
• Preparation and Storage: Store at 4 degree C, for long term storage, store at-20 degree C

Western Blot (WB)

(Figure 1. Western blot analysis using ApoO mouse mAb against HepG2 (1) and 3T3L1(2) cell lysate.)

Immunohistochemistry (IHC)

(Figure 2. Immunohistochemical analysis of paraffin-embedded human Testis tissues using ApoO mouse mAb)

Related Product Information for anti-ApoO antibody

ApoO. apolipoprotein O, also known as MYO25, FAM121B, MGC4825. Entrez Protein NP_077027. It is a chrondroitin-sulfate chain containing member of the apolipoprotein family and is an original glycoprotein up-regulated by diabetes in human Heart. Promotes cholesterol efflux from macrophage cells. Detected in HDL, LDL and VLDL. Secreted by a microsomal triglyceride transfer protein (MTTP)-dependent mechanism, probably as a VLDL-associated protein that is subsequently transferred to HDL. May be involved in myocardium-protective mechanisms against lipid accumulation.

Product Categories/Family for anti-ApoO antibody

Autophagy antibody; Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells

NCBI and Uniprot Product Information

• NCBI GI #: 13129148
• NCBI GeneID: 79135
• NCBI Accession #: NP_077027.1
• NCBI GenBank Nucleotide #: NM_024122.4
• UniProt Accession #: Q9BUR5; Q9H3J9; B2R4K9
• Molecular Weight: 22.2kDa
• NCBI Official Full Name: MICOS complex subunit MIC26
• NCBI Official Synonym Full Names: apolipoprotein O
• NCBI Official Symbol: APOO
• NCBI Official Synonym Symbols: MIC26; Mic23; My025; FAM121B
• NCBI Protein Information: MICOS complex subunit MIC26
• UniProt Protein Name: MICOS complex subunit MIC26
• Protein Family: MICOS complex
• UniProt Gene Name: APOO

NCBI Description

This gene is a member of the apolipoprotein family. Members of this protein family are involved in the transport and metabolism of lipids. The encoded protein associates with HDL, LDL and VLDL lipoproteins and is characterized by chondroitin-sulfate glycosylation. This protein may be involved in preventing lipid accumulation in the myocardium in obese and diabetic patients. Alternative splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 3, 4, 5, 12 and 16.[provided by RefSeq, Sep 2009]

Uniprot Description

Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Plays a crucial role in crista junction formation and mitochondrial function (PubMed:25764979). Can promote cardiac lipotoxicity by enhancing mitochondrial respiration and fatty acid metabolism in cardiac myoblasts (PubMed:24743151). Promotes cholesterol efflux from macrophage cells. Detected in HDL, LDL and VLDL. Secreted by a microsomal triglyceride transfer protein (MTTP)-dependent mechanism, probably as a VLDL-associated protein that is subsequently transferred to HDL (PubMed:16956892).