Western Blot (WB)
(Western Blot: Sample: Recombinant LOXL1, Human.)
Mouse anti-Human Lysyl Oxidase Like Protein 1 (LOXL1) Antibody | anti-LOXL1 antibody
Monoclonal Antibody to Lysyl Oxidase Like Protein 1 (LOXL1)
Immunohistochemistry: 5-20ug/mL
Immunocytochemistry: 5-20ug/mL
Optimal working dilutions must be determined by end user.
Store at 4ºC for frequent use.
Aliquot and store at -20ºC for 24 months.
Stability Test: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
Western Blot (WB)
(Western Blot: Sample: Recombinant LOXL1, Human.)
Western Blot (WB)
(Western Blot: Sample: Recombinant LOXL1, Human.)
Western Blot (WB)
( Western Blot; Sample: Lane 1 Porcine Cerebrum lysate; Lane 2: Rat Cerebrum lysate; Primary Ab: 2 ug/ml Mouse Anti-Human LOXL1 AntibodySecond Ab: 0.2ug/ml HRP-Linked Rabbit Anti-Mouse IgG Polyclonal Antibody(Catalog: MBS2086035))
Western Blot (WB)
( Western Blot; Sample: Lane 1 Porcine Cerebrum lysate; Lane 2: Rat Cerebrum lysate; Primary Ab: 2 ug/ml Mouse Anti-Human LOXL1 AntibodySecond Ab: 0.2ug/ml HRP-Linked Rabbit Anti-Mouse IgG Polyclonal Antibody(Catalog: MBS2086035))
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the lysyl oxidase gene family. The prototypic member of the family is essential to the biogenesis of connective tissue, encoding an extracellular copper-dependent amine oxidase that catalyses the first step in the formation of crosslinks in collagens and elastin. A highly conserved amino acid sequence at the C-terminus end appears to be sufficient for amine oxidase activity, suggesting that each family member may retain this function. The N-terminus is poorly conserved and may impart additional roles in developmental regulation, senescence, tumor suppression, cell growth control, and chemotaxis to each member of the family. [provided by RefSeq, Jul 2008]
Uniprot Description
LOXL1: Active on elastin and collagen substrates. Genetic variations in LOXL1 are a cause of susceptibility to exfoliation syndrome (XFS); also called exfoliation glaucoma (XFG). XFS is a disorder characterized by accumulation of abnormal fibrillar deposits in the anterior segment of the eye. In addition to being a cause of glaucoma and glaucomatous optic neuropathy, exfoliation syndrome has also been associated with lens zonule weakness, cataract formation, and systemic vascular complications due to deposition of exfoliation material in extraocular tissues. Susceptibility to exfoliation syndrome is conferred by a risk haplotype that includes two LOXL1 coding non-synonymous SNPs (Arg141Leu and Gly153Asp) and one intronic SNP. Arg141Leu and Gly153Asp are sufficient to confer disease susceptibility in some populations. Belongs to the lysyl oxidase family.
Protein type: Secreted, signal peptide; Secreted; Extracellular matrix; Oxidoreductase; EC 1.4.3.-
Chromosomal Location of Human Ortholog: 15q22
Cellular Component: extracellular matrix; extracellular space; acrosome; extracellular region; basement membrane
Molecular Function: copper ion binding; oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor
Biological Process: extracellular matrix organization and biogenesis; response to lipopolysaccharide; protein amino acid deamination
Disease: Exfoliation Syndrome
Research Articles on LOXL1
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Product Notes
The LOXL1 loxl1 (Catalog #AAA2012763) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The Monoclonal Antibody to Lysyl Oxidase Like Protein 1 (LOXL1) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's Lysyl Oxidase Like Protein 1 (LOXL1) can be used in a range of immunoassay formats including, but not limited to, Western Blot(WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunoprecipitation (IP). Western blotting: 0.5-2ug/mL Immunohistochemistry: 5-20ug/mL Immunocytochemistry: 5-20ug/mL Optimal working dilutions must be determined by end user. Researchers should empirically determine the suitability of the LOXL1 loxl1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Lysyl Oxidase Like Protein 1 (LOXL1), Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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