Mouse anti-Human E7 Antibody | anti-E7 antibody

E7 Antibody

Cat. Num. AAA850314

• Reactivity: Human
• Applications: Western Blot, Immunohistochemistry, ELISA
• Synonyms: E7; E7 Antibody; HpV16gp2; anti-E7 antibody

• Host: Mouse
• Reactivity: Human
• Isotype: IgG1
• Form/Format: Ascitic fluid containing 0.03% sodium azide.
• Sequence Length: 98

• Applicable Applications for anti-E7 antibody: Western Blot (WB), Immunohistochemistry (IHC), ELISA (EIA)
• Application Notes: WB: 1:500-1:2000; IHC: 1:200-1:1000; ELISA: 1:10000
• Immunogen: Purified recombinant fragment of E7 expressed in E. Coli.
• Preparation and Storage: Store at 4 degree C, for long term storage, store at-20 degree C.

Western Blot (WB)

(Figure 1: Western blot analysis using E7 mAb against recombinant protein.)

Immunohistochemistry (IHC)

(Figure 2: Immunohistochemical analysis of paraffin-embedded placenta tissues (left) and ovarian cancer (right) using E7 mouse mAb with DAB staining.)

Testing Data

Related Product Information for anti-E7 antibody

E7 transforming protein (Human papillomavirus type 16).

Product Categories/Family for anti-E7 antibody

Autophagy antibody; Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells

NCBI and Uniprot Product Information

• NCBI GI #: 9627105
• NCBI GeneID: 1489079
• NCBI Accession #: NP_041326.1
• NCBI GenBank Nucleotide #: NC_001526.4
• UniProt Accession #: P03129
• Molecular Weight: 21kDa
• NCBI Official Full Name: transforming protein E7
• NCBI Official Symbol: E7
• NCBI Protein Information: transforming protein E7
• UniProt Protein Name: Protein E7
• UniProt Gene Name: E7

Uniprot Description

Plays a role in viral genome replication by driving entry of quiescent cells into the cell cycle. Stimulation of progression from G1 to S phase allows the virus to efficiently use the cellular DNA replicating machinery to achieve viral genome replication. E7 protein has both transforming and trans-activating activities. Induces the disassembly of the E2F1 transcription factor from RB1, with subsequent transcriptional activation of E2F1-regulated S-phase genes. Interferes with host histone deacetylation mediated by HDAC1 and HDAC2, leading to transcription activation. Plays also a role in the inhibition of both antiviral and antiproliferative functions of host interferon alpha. Interaction with host TMEM173/STING impairs the ability of TMEM173/STING to sense cytosolic DNA and promote the production of type I interferon (IFN-alpha and IFN-beta).