Mouse anti-Human CD62L Antibody | anti-CD62L antibody

Anti-Hu CD62L PE

Cat. Num. AAA1800922

• Gene Names: SELL; TQ1; LAM1; LEU8; LNHR; LSEL; CD62L; LYAM1; PLNHR; LECAM1
• Reactivity: Human
• Applications: Flow Cytometry, Functional Assay
• Purity: The purified antibody is conjugated with R-phycoerythrin (PE) under optimum conditions. The conjugate is purified by size-exclusion chromatography.
• Synonyms: CD62L; Anti-Hu CD62L PE; selectin L; L-selectin; LSEL; SELL; LAM-1; LAM1; LECAM1; LEU8; LNHR; LYAM1; PLNHR; anti-CD62L antibody

• Host: Mouse
• Reactivity: Human
• Isotype: IgG1
• Clone Number: LT-TD180
• Specificity: The antibody LT-TD180 reacts with an extracellular epitope of CD62L (L-selectin), a 74-95 kDa single chain type I glycoprotein expressed on most peripheral blood B lymphocytes, T lymphocytes, monocytes and granulocytes; it is also present on a subset of NK cells and certain hematopoietic malignant cells.
• Purity/Purification: The purified antibody is conjugated with R-phycoerythrin (PE) under optimum conditions. The conjugate is purified by size-exclusion chromatography.
• Form/Format: Stabilizing phosphate buffered saline (PBS) solution containing 15 mM sodium azide
• Sequence Length: 385

• Applicable Applications for anti-CD62L antibody: Flow Cytometry (FC/FACS)
• Application Notes: FC/FACS: QC tested
• Immunogen: Peripheral blood leukocytes
• Conjugation: PE
• Preparation and Storage: Store in the dark at 2-8 degree C. Do not freeze. Avoid prolonged exposure to light.

Flow Cytometry (FC/FACS)

(Flow cytometry analysis (surface staining) of human peripheral blood cells with anti-CD62L (LT-TD180) PE.)

Related Product Information for anti-CD62L antibody

CD62L (L-selectin) is an adhesion glycoprotein that is constitutively expressed on the cell surface of leukocytes and mediates their homing to inflammatory sites and peripheral lymph nodes by enabling rolling along the venular wall. CD62L is also involved in activation-induced neutrophil aggregation. Activation-dependent CD62L shedding, however, counteracts neutrophil rolling. CD62L has also signaling roles including enhance of chemokine receptor expression. Similarly to CD62P, the major ligand of CD62L is PSGL-1 (P-selectin glycoprotein ligand-1).

NCBI and Uniprot Product Information

• NCBI GI #: 262206315
• NCBI GeneID: 6402
• NCBI Accession #: NP_000646.2
• NCBI GenBank Nucleotide #: NP_000646.2
• UniProt Accession #: P14151
• NCBI Official Full Name: L-selectin
• NCBI Official Synonym Full Names: selectin L
• NCBI Official Symbol: SELL
• NCBI Official Synonym Symbols: TQ1; LAM1; LEU8; LNHR; LSEL; CD62L; LYAM1; PLNHR; LECAM1
• NCBI Protein Information: L-selectin
• UniProt Protein Name: L-selectin
• UniProt Gene Name: SELL
• UniProt Synonym Gene Names: LNHR; LYAM1; LAM-1; LECAM1
• UniProt Entry Name: LYAM1_HUMAN

NCBI Description

This gene encodes a cell surface adhesion molecule that belongs to a family of adhesion/homing receptors. The encoded protein contains a C-type lectin-like domain, a calcium-binding epidermal growth factor-like domain, and two short complement-like repeats. The gene product is required for binding and subsequent rolling of leucocytes on endothelial cells, facilitating their migration into secondary lymphoid organs and inflammation sites. Single-nucleotide polymorphisms in this gene have been associated with various diseases including immunoglobulin A nephropathy. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Oct 2009]

Uniprot Description

SELL: Cell surface adhesion protein. Mediates the adherence of lymphocytes to endothelial cells of high endothelial venules in peripheral lymph nodes. Promotes initial tethering and rolling of leukocytes in endothelia. Belongs to the selectin/LECAM family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 1q23-q25

Cellular Component: integral to plasma membrane; plasma membrane; external side of plasma membrane

Molecular Function: heparin binding; protein binding; protease binding; cell adhesion molecule binding; carbohydrate binding; glycosphingolipid binding

Biological Process: regulation of immune response; cell adhesion; blood coagulation; leukocyte migration; response to ATP

Disease: Iga Nephropathy, Susceptibility To, 1