Mouse Tumor Protein p53 (TP53) ELISA Kit | TP53 elisa kit

Mouse Tumor Protein p53 (TP53) ELISA Kit

Cat. Num. AAA453728

• Gene Names: Trp53; bbl; bfy; bhy; p44; p53; Tp53
• Reactivity: Mouse
• Synonyms: Tumor Protein p53 (TP53); Mouse Tumor Protein p53 (TP53) ELISA Kit; p53; LFS1; TRP53; Li-Fraumeni Syndrome; Cellular tumor antigen p53; Antigen NY-CO-13; Phosphoprotein p53; Tumor suppressor p53; TP53 elisa kit

• Reactivity: Mouse
• Sequence Length: 381

• Samples: Serum, plasma and other biological fluids.
• Assay Type: Sandwich
• Detection Range: 6.25-400pg/mL
• Sensitivity: 2.46pg/mL
• Intra Assay: CV<10%
• Inter Assay: CV<12%
• Preparation and Storage: For unopened kit, all reagents should be kept according to the labels on vials. The TMB Substrate, Wash Buffer, Stop Solution should be stored at 4 degree C. All others should be stored at -20 degree C.

Typical Testing Data/Standard Curve (for reference only)

NCBI and Uniprot Product Information

• NCBI GI #: 187960040
• NCBI GeneID: 22059
• NCBI Accession #: NP_001120705.1
• NCBI GenBank Nucleotide #: NM_001127233.1
• UniProt Accession #: P02340; Q9QUP3
• Molecular Weight: 43,155 Da
• NCBI Official Full Name: cellular tumor antigen p53 isoform b
• NCBI Official Synonym Full Names: transformation related protein 53
• NCBI Official Symbol: Trp53
• NCBI Official Synonym Symbols: bbl; bfy; bhy; p44; p53; Tp53
• NCBI Protein Information: cellular tumor antigen p53
• UniProt Protein Name: Cellular tumor antigen p53
• Protein Family: Cellular tumor antigen
• UniProt Gene Name: Tp53
• UniProt Synonym Gene Names: P53; Trp53

NCBI Description

This gene encodes tumor protein p53, which responds to diverse cellular stresses to regulate target genes that induce cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. p53 protein is expressed at low level in normal cells and at a high level in a variety of transformed cell lines, where it's believed to contribute to transformation and malignancy. p53 is a DNA-binding protein containing transcription activation, DNA-binding, and oligomerization domains. It is postulated to bind to a p53-binding site and activate expression of downstream genes that inhibit growth and/or invasion, and thus function as a tumor suppressor. Mice deficient for this gene are developmentally normal but are susceptible to spontaneous tumors. Evidence to date shows that this gene contains one promoter, in contrast to alternative promoters of the human gene, and transcribes a few of splice variants which encode different isoforms, although the biological validity or the full-length nature of some variants has not been determined. [provided by RefSeq, Jul 2008]

Uniprot Description

Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. In cooperation with mitochondrial PPIF is involved in activating oxidative stress-induced necrosis; the function is largely independent of transcription. Prevents CDK7 kinase activity when associated to CAK complex in response to DNA damage, thus stopping cell cycle progression (). Induces the transcription of long intergenic non-coding RNA p21 (lincRNA-p21) and lincRNA-Mkln1. LincRNA-p21 participates in TP53-dependent transcriptional repression leading to apoptosis, but seems to have to effect on cell-cycle regulation. Regulates the circadian clock by repressing CLOCK-ARNTL/BMAL1-mediated transcriptional activation of PER2 (PubMed:24051492).