Typical Testing Data/Standard Curve (for reference only)
(Fig.1. Mouse TOM1-like protein 1 (TOM1L1) Standard Curve.)
Mouse TOM1-Like Protein 1 (TOM1L1) ELISA Kit | TOM1L1 elisa kit
Mouse TOM1-Like Protein 1 (TOM1L1) ELISA Kit
* Allow all reagents to warm to room temperature for at least 30 minutes before opening.
* Pre-rinse the pipet tip with reagent, use fresh pipet tips for each sample, standard and reagent to avoid contamination.
* Unused wells must be kept desiccated at 4 degree C in the sealed bag provided.
* Mix Thoroughly is very important for the result. It is recommended using low frequency oscillator or slight hand shaking every 10 minutes.
* It is recommended that all samples and standards be assayed in duplicate or triplicate.
Typical Testing Data/Standard Curve (for reference only)
(Fig.1. Mouse TOM1-like protein 1 (TOM1L1) Standard Curve.)
Typical Testing Data/Standard Curve (for reference only)
(Fig.1. Mouse TOM1-like protein 1 (TOM1L1) Standard Curve.)
Background: Mice hypomorphic for Tom1l2 exhibited numerous infections and tumors compared to wild-type littermates. Associated with this increased risk for infection and tumor formation, apparently healthy Tom1l2 hypomorphs also had splenomegaly, elevated B- and T-cell counts, and an impaired humoral response, although at a reduced penetrance. Furthermore, cellular localization studies showed that a Tom1l2-GFP fusion protein colocalizes with Golgi compartments, supporting the role of Tom1l2 in cellular trafficking, while molecular modeling and bioinformatic analysis of Tom1l2 illustrated a structural basis for a functional role in trafficking. These results indicate a role for Tom1l2 in the immune response and possibly in tumor suppression.
NCBI and Uniprot Product Information
Uniprot Description
Srcasm: an adapter protein that is a src-family kinase substrate. When phosphorylated, it binds src-family kinases and targets them for lysosomal-dependent degradation. EGF triggers a transient association of phosphorylated Srcasm with EGFR via Grb2 and Shc initiating the endocytosis of the ligand-receptor complex. Interacts with the SH2 and SH3 domains of various signaling proteins when it is phosphorylated. Involved in multivesicular body (MVB) formation, viral egress from the cell, and cytokinesis. Belongs to the TOM1 family. Interacts with FYN, GRB2 and PIK3R1 when phosphorylated. The PTAP sequence in the GAT domain and the PSAP sequence in the C-terminal region are responsible for its interaction with the UEV domain of Tsg101, a component of the ESCRT-1 complex. Localizes to the multivesicular body (MVB) that is involved in targeting endosomal proteins for lysosomal degradation.
Protein type: Adaptor/scaffold
Cellular Component: Golgi apparatus; membrane; cytoplasm; intracellular; cytosol; endosome
Molecular Function: protein binding; clathrin binding; SH3 domain binding; protein kinase activator activity; protein kinase binding
Biological Process: intracellular protein transport; protein transport; transport; positive regulation of protein kinase activity; negative regulation of mitosis; activation of protein kinase activity; signal transduction; positive regulation of protein amino acid autophosphorylation; transmembrane receptor protein tyrosine kinase signaling pathway
Research Articles on TOM1L1
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Product Notes
The Mouse TOM1L1 tom1l1 (Catalog #AAA9716689) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9716689 ELISA Kit recognizes Mouse TOM1L1. It is sometimes possible for the material contained within the vial of "TOM1-Like Protein 1 (TOM1L1), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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