Typical Testing Data/Standard Curve (for reference only)
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Mouse Toll/Interleukin-1 Receptor Domain-Containing Adapter Protein (TIRAP) ELISA Kit | TIRAP elisa kit
Mouse Toll/Interleukin-1 Receptor Domain-Containing Adapter Protein (TIRAP) ELISA Kit
Typical Testing Data/Standard Curve (for reference only)
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Typical Testing Data/Standard Curve (for reference only)
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Background/Introduction: TIRAP is a TIR adaptor protein involved in the TLR4 signaling pathway of the immune system. It activates NF-kappa-B, MAPK1, MAPK3 and JNK, which then results in cytokine secretion and the inflammatory response. Alternative splicing of this gene results in several transcript variants; however, not all variants have been fully described.
NCBI and Uniprot Product Information
Uniprot Description
TIRAP: an adapter protein involved in the TLR4 signaling pathway in the innate immune response. Acts via IRAK2 and TRAF-6, leading to the activation of NF-kappa-B, ERK1, ERK2 and JNK, resulting in cytokine secretion and the inflammatory response. Homodimerizes. Also forms heterodimers with MyD88. Binds to TLR4 and IRAK2 via their respective TIR domains. Binds to PKR and TBK1. Does not interact with IRAK1, nor TLR9. Genetic variations in TIRAP can influence susceptibility or resistance to infectious diseases, including invasive pneumococcal disease, malaria and tuberculosis. Three isoforms of the human protein are produced by alternative splicing.
Protein type: Adaptor/scaffold
Cellular Component: nucleoplasm; intercellular bridge; membrane; endocytic vesicle; cytoplasm; plasma membrane; peroxisome; intracellular
Molecular Function: protein binding; phosphatidylinositol-4,5-bisphosphate binding; protein homodimerization activity; protein kinase C binding; protein heterodimerization activity
Biological Process: I-kappaB kinase/NF-kappaB cascade; positive regulation of interleukin-12 production; positive regulation of interleukin-6 biosynthetic process; positive regulation of JNK cascade; response to lipopolysaccharide; signal transduction; activation of JNK activity; activation of NF-kappaB transcription factor; positive regulation of interleukin-8 production; toll-like receptor 5 signaling pathway; cell surface receptor linked signal transduction; positive regulation of interleukin-15 production; positive regulation of innate immune response; positive regulation of B cell proliferation; inflammatory response; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of toll-like receptor 3 signaling pathway; immune system process; positive regulation of toll-like receptor 4 signaling pathway; positive regulation of tumor necrosis factor production; regulation of interleukin-15 production; positive regulation of toll-like receptor 2 signaling pathway; regulation of innate immune response; defense response to Gram-positive bacterium; response to bacterium; innate immune response; myeloid cell differentiation; regulation of interferon-beta production
Research Articles on TIRAP
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Product Notes
The Mouse TIRAP tirap (Catalog #AAA9716830) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9716830 ELISA Kit recognizes Mouse TIRAP. It is sometimes possible for the material contained within the vial of "Toll/Interleukin-1 Receptor Domain-Containing Adapter Protein (TIRAP), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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