Typical Testing Data/Standard Curve (for reference only)
(Mouse TNFSF4/OX40L PicoKine ELISA Kit standard curve )
Mouse TNFSF4/OX40L ELISA Kit | TNFSF4 elisa kit
Mouse TNFSF4/OX40L PicoKine ELISA Kit
Typical Testing Data/Standard Curve (for reference only)
(Mouse TNFSF4/OX40L PicoKine ELISA Kit standard curve )
Typical Testing Data/Standard Curve (for reference only)
(Mouse TNFSF4/OX40L PicoKine ELISA Kit standard curve )
Background: OX40L is the ligand for CD134 and is expressed on such cells as DC2s enabling amplification of Th2 cell differentiation. OX40L has also been designated CD252. By analysis of an interspecific backcross, Baum et al. (1994) mapped the mouse Tnfsf4 gene to chromosome 1. Using fluorescence in situ hybridization, they localized the human TNFSF4 gene to 1q25, a region sharing homology of synteny with the portion of mouse chromosome 1 containing the Tnfsf4 gene.OX40L strongly inhibited the generation of IL-10-producing Tr1 cells induced by two physiologic stimuli, the inducible costimulatory ligand and immature dendritic cells. In addition, OX40L strongly inhibited IL-10 production and suppressive function of differentiated IL-10-producing Tr1 cells. Tnfsf4 underlies Ath1 in mice and that polymorphisms in its human homolog TNFSF4 increase the risk of myocardial infarction in humans.
NCBI and Uniprot Product Information
Uniprot Description
TNFSF4: Cytokine that binds to TNFRSF4. Co-stimulates T-cell proliferation and cytokine production. Genetic variations in TNFSF4 influence susceptibility to systemic lupus erythematosus (SLE). SLE is a chronic, inflammatory and often febrile multisystemic disorder of connective tissue. It affects principally the skin, joints, kidneys and serosal membranes. It is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The upstream region of TNFSF4 contains a single risk haplotype for SLE, which is correlated with increased expression of both cell-surface TNFSF4 and TNFSF4 transcripts. Increased levels of TNFSF4 are thought to augment T-cell-APC interaction and the functional consequences of T-cell activation, thereby destabilizing peripheral tolerance. Belongs to the tumor necrosis factor family.
Protein type: Cell cycle regulation; Membrane protein, integral; Cytokine
Cellular Component: extracellular space; cell surface; membrane; integral to membrane
Molecular Function: cytokine activity; tumor necrosis factor receptor superfamily binding; tumor necrosis factor receptor binding
Biological Process: negative regulation of T-helper 1 cell differentiation; positive regulation of interleukin-12 production; negative regulation of cytokine secretion; positive regulation of T cell cytokine production; positive regulation of activated T cell proliferation; defense response to nematode; positive regulation of interleukin-10 production; positive regulation of interleukin-4 production; T cell proliferation; positive regulation of immune effector process; regulation of adaptive immune response; positive regulation of T-helper 2 cell differentiation; negative regulation of regulatory T cell differentiation; negative regulation of interferon-gamma production; positive regulation of interleukin-13 production; inflammatory response; positive regulation of memory T cell differentiation; blood vessel development; cholesterol metabolic process; positive regulation of T-helper 2 type immune response; negative regulation of transcription factor activity; response to virus; positive regulation of immunoglobulin mediated immune response; cytokine production; positive regulation of interleukin-6 production; positive regulation of CD4-positive, alpha beta T cell differentiation; positive regulation of immunoglobulin secretion; positive regulation of interferon-gamma production; negative regulation of interleukin-17 production; positive regulation of B cell activation; regulation of inflammatory response; positive regulation of interleukin-2 production; innate immune response; immune response; positive regulation of alpha-beta T cell proliferation; negative regulation of transcription, DNA-dependent; acute inflammatory response; positive regulation of inflammatory response
Research Articles on TNFSF4
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Product Notes
The Mouse TNFSF4 tnfsf4 (Catalog #AAA177228) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA177228 ELISA Kit recognizes Mouse TNFSF4. It is sometimes possible for the material contained within the vial of "TNFSF4/OX40L, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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