OX40 Ligand/TNFSF4 Active Protein | TNFSF4 active protein

Human CellExp OX40 Ligand/TNFSF4, Mouse Recombinant

Cat. Num. AAA849859

• Gene Names: Tnfsf4; Ath1; gp34; Ath-1; Ox40l; TXGP1; CD134L; OX-40L; Txgp1l
• Purity: >90% by SDS-PAGE
• Synonyms: OX40 Ligand/TNFSF4; Human CellExp OX40 Ligand/TNFSF4; Mouse Recombinant; OX40L; TNFSF4; CD252; Glycoprotein Gp34; TXGP1; TNFSF4 active protein

• Host: HEK293 cells
• Purity/Purification: >90% by SDS-PAGE
• Form/Format: Lyophilized from 0.22 um filtered solution in PBS, pH7.4. Generally Mannitol or Trehalose is added as a protectant before lyophilization.

• Gene Source: Mouse
• Endotoxin: <1.0 EU per/ug
• Biological Activity: Immobilized Mouse OX40, Fc Tag at 5 ug/mL (100 uL/well) can bind Mouse OX40 Ligand, His Tag with a linear range of 0.5-16 ng/mL; Measured by its binding ability in a functional ELISA.
• Reconstitution Instruction: Reconstitute in sterile deionized water to the desired protein concentration.
• Preparation and Storage: Store at -20 degree C; Centrifuge the vial prior to opening.; Shelf life: ~12 months

SDS-Page

Testing Data

Related Product Information for TNFSF4 active protein

Members of the dickkopf-related protein family (DKK-1, -2, -3, and -4) are secreted proteins with two cysteine-rich domains separated by a linker region. And DKK3 has been proposed as tumour suppressor gene and a marker for tumour blood vessels. DKK3 is the only DKK family member abundantly expressed in normal lung, but silenced by promoter hypermethylation in a large fraction of lung cancer cell lines and lung tumors. Downregulation of DKK3 was correlated with tumor progression and expression of nuclear beta-catenin in lung tumors. Ectopic expression of DKK3 in lung cancer cells with DKK3 hypermethylation induced apoptosis and inhibited TCF-4 activity as well as nuclear accumulation of beta-catenin and expression of TCF-4 targets c-Myc and cyclin D1. DKK3 modulates FGF and Activin/Nodal signaling to regulate mesoderm induction during early Xenopus development, was reported.

Product Categories/Family for TNFSF4 active protein

Proteins; Enzymes; Human cell expressed recombinant proteins; Cytokines; Growth Factors & Hormones; Cytokines & Growth Factors (A-Z); Proteins & Enzymes (A-Z); Signaling Pathways; NF kappaB Signaling; Animal Free Origin (AOF); Recombinant Proteins & Enzym

NCBI and Uniprot Product Information

• NCBI GI #: 1171934
• NCBI GeneID: 22164
• UniProt Accession #: P43488
• Molecular Weight: 22,255 Da
• NCBI Official Full Name: Tumor necrosis factor ligand superfamily member 4
• NCBI Official Synonym Full Names: tumor necrosis factor (ligand) superfamily, member 4
• NCBI Official Symbol: Tnfsf4
• NCBI Official Synonym Symbols: Ath1; gp34; Ath-1; Ox40l; TXGP1; CD134L; OX-40L; Txgp1l
• NCBI Protein Information: tumor necrosis factor ligand superfamily member 4; OX40 ligand; atherosclerosis 1; tax-transcriptionally activated glycoprotein 1 ligand
• UniProt Protein Name: Tumor necrosis factor ligand superfamily member 4
• Protein Family: Tumor necrosis factor ligand superfamily
• UniProt Gene Name: Tnfsf4
• UniProt Synonym Gene Names: Ox40l; Txgp1l; OX40L
• UniProt Entry Name: TNFL4_MOUSE

Uniprot Description

TNFSF4: Cytokine that binds to TNFRSF4. Co-stimulates T-cell proliferation and cytokine production. Genetic variations in TNFSF4 influence susceptibility to systemic lupus erythematosus (SLE). SLE is a chronic, inflammatory and often febrile multisystemic disorder of connective tissue. It affects principally the skin, joints, kidneys and serosal membranes. It is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The upstream region of TNFSF4 contains a single risk haplotype for SLE, which is correlated with increased expression of both cell-surface TNFSF4 and TNFSF4 transcripts. Increased levels of TNFSF4 are thought to augment T-cell-APC interaction and the functional consequences of T-cell activation, thereby destabilizing peripheral tolerance. Belongs to the tumor necrosis factor family.

Protein type: Cell cycle regulation; Membrane protein, integral; Cytokine

Cellular Component: extracellular space; cell surface; membrane; integral to membrane

Molecular Function: cytokine activity; tumor necrosis factor receptor superfamily binding; tumor necrosis factor receptor binding

Biological Process: negative regulation of T-helper 1 cell differentiation; positive regulation of interleukin-12 production; negative regulation of cytokine secretion; positive regulation of T cell cytokine production; positive regulation of activated T cell proliferation; defense response to nematode; positive regulation of interleukin-10 production; positive regulation of interleukin-4 production; T cell proliferation; positive regulation of immune effector process; regulation of adaptive immune response; positive regulation of T-helper 2 cell differentiation; negative regulation of regulatory T cell differentiation; negative regulation of interferon-gamma production; positive regulation of interleukin-13 production; inflammatory response; positive regulation of memory T cell differentiation; blood vessel development; cholesterol metabolic process; positive regulation of T-helper 2 type immune response; negative regulation of transcription factor activity; response to virus; positive regulation of immunoglobulin mediated immune response; cytokine production; positive regulation of interleukin-6 production; positive regulation of CD4-positive, alpha beta T cell differentiation; positive regulation of immunoglobulin secretion; positive regulation of interferon-gamma production; negative regulation of interleukin-17 production; positive regulation of B cell activation; regulation of inflammatory response; positive regulation of interleukin-2 production; innate immune response; immune response; positive regulation of alpha-beta T cell proliferation; negative regulation of transcription, DNA-dependent; acute inflammatory response; positive regulation of inflammatory response