Mouse Sirtuin 6 (SIRT6) ELISA Kit | SIRT6 elisa kit

Mouse Sirtuin 6 (SIRT6) ELISA Kit

Cat. Num. AAA453008

• Gene Names: Sirt6; Sir2l6; AI043036; 2810449N18Rik
• Reactivity: Mouse
• Synonyms: Sirtuin 6 (SIRT6); Mouse Sirtuin 6 (SIRT6) ELISA Kit; SIR2L6; Silent Mating Type Information Regulation 2 Homolog 6; Mono-ADP-Ribosyltransferase Sirtuin-6; Regulatory protein SIR2 homolog 6; SIR2-like protein 6; SIRT6 elisa kit

• Reactivity: Mouse
• Sequence Length: 334

• Samples: Tissue homogenates, cell lysates and other biological fluids.
• Assay Type: Sandwich
• Detection Range: 0.156-10ng/mL
• Sensitivity: 0.063ng/mL
• Intra Assay: CV<10%
• Inter Assay: CV<12%
• Preparation and Storage: For unopened kit, all reagents should be kept according to the labels on vials. The TMB Substrate, Wash Buffer, Stop Solution should be stored at 4 degree C. All others should be stored at -20 degree C.

Typical Testing Data/Standard Curve (for reference only)

NCBI and Uniprot Product Information

• NCBI GI #: 31712018
• NCBI GeneID: 50721
• NCBI Accession #: NP_853617.1
• NCBI GenBank Nucleotide #: NM_181586.3
• UniProt Accession #: P59941
• Molecular Weight: 36,920 Da
• NCBI Official Full Name: NAD-dependent protein deacetylase sirtuin-6 isoform 1
• NCBI Official Synonym Full Names: sirtuin 6
• NCBI Official Symbol: Sirt6
• NCBI Official Synonym Symbols: Sir2l6; AI043036; 2810449N18Rik
• NCBI Protein Information: NAD-dependent protein deacetylase sirtuin-6
• UniProt Protein Name: NAD-dependent protein deacetylase sirtuin-6
• Protein Family: NAD-dependent protein deacetylase
• UniProt Gene Name: Sirt6
• UniProt Synonym Gene Names: Sir2l6

Uniprot Description

NAD-dependent protein deacetylase. Has deacetylase activity towards histone H3K9Ac and H3K56Ac. Modulates acetylation of histone H3 in telomeric chromatin during the S-phase of the cell cycle. Deacetylates histone H3K9Ac at NF-kappa-B target promoters and may down-regulate the expression of a subset of NF-kappa-B target genes. Deacetylation of nucleosomes interferes with RELA binding to target DNA. May be required for the association of WRN with telomeres during S-phase and for normal telomere maintenance. On DNA damage, promotes DNA end resection via deacetylation of RBBP8. Has very weak deacetylase activity and can bind NAD+ in the absence of acetylated substrate (). Acts as a corepressor of the transcription factor Hif1a to control the expression of multiple glycolytic genes to regulate glucose homeostasis. Required for genomic stability. Required for normal IGF1 serum levels and normal glucose homeostasis. Modulates cellular senescence and apoptosis. Regulates the production of TNF protein. Has a role in the regulation of life span in male mice, but not in female mice.