Mouse Lecithin Cholesterol Acyltransferase (LCAT) ELISA Kit | LCAT elisa kit

Mouse Lecithin Cholesterol Acyltransferase (LCAT) ELISA Kit

Cat. Num. AAA453394

• Gene Names: Lcat; AI046659; D8Wsu61e
• Reactivity: Mouse
• Synonyms: Lecithin Cholesterol Acyltransferase (LCAT); Mouse Lecithin Cholesterol Acyltransferase (LCAT) ELISA Kit; phosphatidylcholine-sterol O-acyltransferase; Phospholipid-cholesterol acyltransferase; LCAT elisa kit

• Reactivity: Mouse
• Sequence Length: 438

• Samples: Serum, plasma, tissue homogenates and other biological fluids.
• Assay Type: Sandwich
• Detection Range: 15.625-1000pg/mL
• Sensitivity: 6.9pg/mL
• Intra Assay: CV<10%
• Inter Assay: CV<12%
• Preparation and Storage: For unopened kit, all reagents should be kept according to the labels on vials. The TMB Substrate, Wash Buffer, Stop Solution should be stored at 4 degree C. All others should be stored at -20 degree C.

Typical Standard Curve/Testing Data

NCBI and Uniprot Product Information

• NCBI GI #: 244791354
• NCBI GeneID: 16816
• NCBI Accession #: NP_032516.2
• NCBI GenBank Nucleotide #: NM_008490.2
• UniProt Accession #: P16301; Q8K139
• Molecular Weight: 49,747 Da
• NCBI Official Full Name: phosphatidylcholine-sterol acyltransferase
• NCBI Official Synonym Full Names: lecithin cholesterol acyltransferase
• NCBI Official Symbol: Lcat
• NCBI Official Synonym Symbols: AI046659; D8Wsu61e
• NCBI Protein Information: phosphatidylcholine-sterol acyltransferase
• UniProt Protein Name: Phosphatidylcholine-sterol acyltransferase
• UniProt Gene Name: Lcat

Uniprot Description

Central enzyme in the extracellular metabolism of plasma lipoproteins. Synthesized mainly in the liver and secreted into plasma where it converts cholesterol and phosphatidylcholines (lecithins) to cholesteryl esters and lysophosphatidylcholines on the surface of high and low density lipoproteins (HDLs and LDLs) (PubMed:19065001). The cholesterol ester is then transported back to the liver. Also produced in the brain by primary astrocytes, and esterifies free cholesterol on nascent APOE-containing lipoproteins secreted from glia and influences cerebral spinal fluid (CSF) APOE- and APOA1 levels (PubMed:19065001). Together with APOE and the cholesterol transporter ABCA1, plays a key role in the maturation of glial-derived, nascent lipoproteins (PubMed:19065001). Required for remodeling high-density lipoprotein particles into their spherical forms (PubMed:19065001). Has a preference for plasma 16:0-18:2 or 18:O-18:2 phosphatidylcholines (PubMed:8820107).