Mouse KIAA1530 ELISA Kit | KIAA1530 elisa kit
Mouse Uncharacterized protein KIAA1530, KIAA1530 ELISA Kit
NCBI and Uniprot Product Information
Uniprot Description
UVSSA: Factor involved in transcription-coupled nucleotide excision repair (TC-NER) in response to UV damage. TC-NER allows RNA polymerase II-blocking lesions to be rapidly removed from the transcribed strand of active genes. Acts by promoting stabilization of ERCC6 by recruiting deubiquitinating enzyme USP7 to TC-NER complexes, preventing UV-induced degradation of ERCC6 by the proteasome. Interacts with the elongating form of RNA polymerase II (RNA pol IIo) and facilitates its ubiquitination at UV damage sites, leading to promote RNA pol IIo backtracking to allow access to the nucleotide excision repair machinery. Not involved in processing oxidative damage. Defects in UVSSA are a cause of UV-sensitive syndrome type 3 (UVSS3). A rare autosomal recessive disorder characterized by photosensitivity and mild freckling but without neurological abnormalities or skin tumors. Belongs to the UVSSA family. 2 isoforms of the human protein are produced by alternative splicing.
Cellular Component: chromosome
Biological Process: transcription-coupled nucleotide-excision repair; protein ubiquitination; DNA repair; response to DNA damage stimulus; response to UV
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Product Notes
The Mouse KIAA1530 uvssa (Catalog #AAA9329465) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9329465 ELISA Kit recognizes Mouse KIAA1530. It is sometimes possible for the material contained within the vial of "KIAA1530, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
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