Mouse Haptoglobin ELISA Kit | HP elisa kit
Mouse Haptoglobin ELISA Kit
Background: Acute phase proteins are plasma proteins which increase in concentration following infection, inflammation or trauma. The first acute phase protein to be recognized was discovered in humans by Tillet and Frances in 19301. Haptoglobin (Hp) is a heterogeneous plasma protein mostly synthesized in by the liver. The haptoglobin monomer consist of two heavy chains, beta chains (40 kD) and two light chains, alpha chains, alpha 1 (9 kD) and alpha 2 (16 kD) that are linked disulfide bonds. The three major haptoglobin types are; Hp1-1 which is monomeric (98kD), Hp1-2 is polymeric at about 200 kD, and Hp2-2 at about 400 kD. The haptoglobin level in serum rise quickly following acute tissue damage within 24 to 48 hours and also falls very rapidly once the stimulus is removed. In fact, Hp level are decreased in hemolytic anemia. Hp has a high affinity for hemoglobin (Hb) and its function appears to be to prevent loss of Hb in urine which would lead to loss of iron. Investigations over the past few years have shown that quantification of Hp in plasma or serum can provide valuable information in the detection, prognosis, and monitoring of disease not only in humans, but in companion animals and farm herds as well2.
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a preproprotein, which is processed to yield both alpha and beta chains, which subsequently combine as a tetramer to produce haptoglobin. Haptoglobin functions to bind free plasma hemoglobin, which allows degradative enzymes to gain access to the hemoglobin, while at the same time preventing loss of iron through the kidneys and protecting the kidneys from damage by hemoglobin. Mutations in this gene and/or its regulatory regions cause ahaptoglobinemia or hypohaptoglobinemia. This gene has also been linked to diabetic nephropathy, the incidence of coronary artery disease in type 1 diabetes, Crohn's disease, inflammatory disease behavior, primary sclerosing cholangitis, susceptibility to idiopathic Parkinson's disease, and a reduced incidence of Plasmodium falciparum malaria. A similar duplicated gene is located next to this gene on chromosome 16. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]
Uniprot Description
HP: Haptoglobin combines with free plasma hemoglobin, preventing loss of iron through the kidneys and protecting the kidneys from damage by hemoglobin, while making the hemoglobin accessible to degradative enzymes. Defects in HP are the cause of anhaptoglobinemia (AHP). AHP is a condition characterized by the absence of the serum glycoprotein haptoglobin. Serum levels of haptoglobin vary among normal persons: levels are low in the neonatal period and in the elderly, differ by population, and can be influenced by environmental factors, such as infection. Secondary hypohaptoglobinemia can occur as a consequence of hemolysis, during which haptoglobin binds to free hemoglobin. Belongs to the peptidase S1 family.
Protein type: Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 16q22.2
Cellular Component: extracellular space; extracellular region
Molecular Function: antioxidant activity; protein binding; hemoglobin binding; catalytic activity
Biological Process: receptor-mediated endocytosis; response to hydrogen peroxide; metabolic process; immune system process; defense response to bacterium; negative regulation of oxidoreductase activity; acute-phase response; defense response
Disease: Anhaptoglobinemia
Research Articles on HP
2. Specific Hp polymorphisms may be associated with cGVHD development and warrant further investigation.
3. the influences of the haptoglobin, MnSOD, CAT, GPX1, ACE, glutathione S-transferases M1 (GSTM1) and T1 (GSTT1) genes' polymorphisms on the oxidative stress and damage suffered by human runners was studied
4. The results extend previous observations that Hp2-2 is associated with clinical cardiovascular disease in diabetes.
5. Haptoglobin may be a potential useful biomarker for diagnosis or a medicine target for treatment of neuromyelitis optica.
6. Results suggest an association between haptoglobin (Hp) genotypes and the severity of heart complications in Chagas' disease.
7. Our data show that Haptoglobin is a novel monocyte chemoattractant and that its chemotactic potential is mediated, at least in part. by its interaction with CCR2.
8. Our results have identified, for the first time, unique patterns of haptoglobin mRNA expression and protein localization in the stromal and glandular epithelial cells of endometrioid adenocarcinoma of the uterus.
9. Genetic polymorphisms of SLC2A2 and HP is associated with serum cholesterol levels.
10. analysis of the N-glycosylation status of beta-haptoglobin in sera of patients with prostate cancer vs. benign prostate diseases
11. Results identified haptoglobin alpha-1, apolipoprotein C-I and apolipoprotein C-III as candidate biomarkers in PTC.
12. we have now identified human zonulin as the precursor for haptoglobin-2 (pre-HP2).
13. We did not find any association between HP genotypes and type 2 diabetes or the anthropometric and clinical features examined in the population studied.
14. under conditions of severe inflammation and oxidative stress, peroxidase activity of Hb-Hp covalent aggregates may cause macrophage dysfunction and microvascular vasoconstriction
15. Haptoglobin genotype is closely related to recurrence rate inpatients with HNSCC.
16. haptoglobin and serum amyloid A may have roles in atherothrombotic ischemic stroke
17. Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
18. Meta-analysis of gene-disease association. (HuGE Navigator)
19. These results indicate that haptoglobin (Hp)improves endothelial progenitor cells (EPCs) function in neovasculogenesis, which suggests that ex vivo modification of EPCs with the Hp gene can be applied to the treatment of vascular damage.
20. HDL can become proinflammatory via the hemoglobin x Hp pathway in mice and humans
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Product Notes
The Mouse HP hp (Catalog #AAA564070) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA564070 ELISA Kit recognizes Mouse HP. It is sometimes possible for the material contained within the vial of "Haptoglobin, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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