Mouse Glutamate receptor delta-2 subunit (GRID2) ELISA Kit | GRID2 elisa kit
Mouse Glutamate receptor delta-2 subunit (GRID2) ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is a member of the family of ionotropic glutamate receptors which are the predominant excitatory neurotransmitter receptors in the mammalian brain. The encoded protein is a multi-pass membrane protein that is expressed selectively in cerebellar Purkinje cells. A point mutation in the mouse ortholog, associated with the phenotype named 'lurcher', in the heterozygous state leads to ataxia resulting from selective, cell-autonomous apoptosis of cerebellar Purkinje cells during postnatal development. Mice homozygous for this mutation die shortly after birth from massive loss of mid- and hindbrain neurons during late embryogenesis. This protein also plays a role in synapse organization between parallel fibers and Purkinje cells. Alternate splicing results in multiple transcript variants encoding distinct isoforms. Mutations in this gene cause cerebellar ataxia in humans. [provided by RefSeq, Apr 2014]
Uniprot Description
GluR-delta2: Receptor for glutamate. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. GRID2 subfamily.
Protein type: Channel, ligand-gated; Membrane protein, integral; Channel, calcium; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 4q22
Cellular Component: postsynaptic membrane; integral to plasma membrane; dendrite; plasma membrane; dendritic spine; ionotropic glutamate receptor complex; synapse; cell junction
Molecular Function: extracellular-glutamate-gated ion channel activity; ionotropic glutamate receptor activity; glutamate receptor activity; PDZ domain binding
Biological Process: heterophilic cell adhesion; synaptic transmission, glutamatergic; prepulse inhibition; glutamate signaling pathway; ionotropic glutamate receptor signaling pathway; transport; regulation of neuron apoptosis; regulation of excitatory postsynaptic membrane potential; cerebellar granule cell differentiation
Disease: Spinocerebellar Ataxia, Autosomal Recessive 18
Research Articles on GRID2
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Product Notes
The Mouse GRID2 grid2 (Catalog #AAA7224352) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA7224352 ELISA Kit recognizes Mouse GRID2. It is sometimes possible for the material contained within the vial of "Glutamate receptor delta-2 subunit (GRID2), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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