Western Blot (WB)
(DCPS Antibody (Center) western blot analysis in NCI-H460 cell line lysates (35ug/lane).This demonstrates the DCPS antibody detected the DCPS protein (arrow).)
Rabbit DCPS Polyclonal Antibody | anti-DCPS antibody
DCPS Antibody (Center)
Gene Names
DCPS; DCS1; HSL1; HINT5; HINT-5; HSPC015
Reactivity
Human (Predicted Reactivity: Bovine, Mouse, Pig, Rat)
Applications
Western Blot, ELISA
Purity
Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Synonyms
DCPS; Polyclonal Antibody; DCPS Antibody (Center); m7GpppX diphosphatase; DCS-1; Decapping scavenger enzyme; Hint-related 7meGMP-directed hydrolase; Histidine triad nucleotide-binding protein 5; Histidine triad protein member 5; HINT-5; Scavenger mRNA-decapping enzyme DcpS; DCS1; HINT5; anti-DCPS antibody
Host
Rabbit
Reactivity
Human (Predicted Reactivity: Bovine, Mouse, Pig, Rat)
Clonality
Polyclonal
Isotype
Rabbit Ig
Specificity
This DCPS antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 165-193 amino acids from the Central region of human DCPS.
Purity/Purification
Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Form/Format
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Vial Concentration: 0.45 (varies by lot)
Sequence Positions
165-193
Sequence Length
337
Applicable Applications for anti-DCPS antibody
Western Blot (WB), ELISA (EIA)
Application Notes
WB~~1:1000
Antigen Type
Synthetic Peptide
Antigen Source
HUMAN
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
Western Blot (WB)
(DCPS Antibody (Center) western blot analysis in NCI-H460 cell line lysates (35ug/lane).This demonstrates the DCPS antibody detected the DCPS protein (arrow).)
Western Blot (WB)
(DCPS Antibody (Center) western blot analysis in NCI-H460 cell line lysates (35ug/lane).This demonstrates the DCPS antibody detected the DCPS protein (arrow).)
Related Product Information for anti-DCPS antibody
Necessary for the complete degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. Removes the 7-methyl guanine cap structure from mRNA fragments shorter than 10 nucleotides that are produced by 3'->5' exosome-mediated mRNA decay. Releases m7GMP. Can also degrade m7GDP to m7GMP. Has no activity towards mRNA molecules longer than 25 nucleotides.
References
Sebastiani, P., et al. Science (2010) In press :
Mariller, C., et al. Biochimie 91(1):109-122(2009)
Liu, S.W., et al. J. Biol. Chem. 283(24):16427-16436(2008)
Shen, V., et al. RNA 14(6):1132-1142(2008)
Lamesch, P., et al. Genomics 89(3):307-315(2007)
Mariller, C., et al. Biochimie 91(1):109-122(2009)
Liu, S.W., et al. J. Biol. Chem. 283(24):16427-16436(2008)
Shen, V., et al. RNA 14(6):1132-1142(2008)
Lamesch, P., et al. Genomics 89(3):307-315(2007)
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
38609
NCBI Official Full Name
m7GpppX diphosphatase
NCBI Official Synonym Full Names
decapping enzyme, scavenger
NCBI Official Symbol
DCPS
NCBI Official Synonym Symbols
DCS1; HSL1; HINT5; HINT-5; HSPC015
NCBI Protein Information
m7GpppX diphosphatase
UniProt Protein Name
m7GpppX diphosphatase
Protein Family
UniProt Gene Name
DCPS
UniProt Synonym Gene Names
DCS1; HINT5; HINT-5
UniProt Entry Name
DCPS_HUMAN
Uniprot Description
DCPS: Necessary for the complete degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. Removes the 7-methyl guanine cap structure from mRNA fragments shorter than 10 nucleotides that are produced by 3'->5' exosome-mediated mRNA decay. Releases m7GMP. Can also degrade m7GDP to m7GMP. Has no activity towards mRNA molecules longer than 25 nucleotides. Belongs to the HIT family.
Protein type: EC 3.6.1.59; Hydrolase; RNA splicing
Chromosomal Location of Human Ortholog: 11q24.2
Cellular Component: nucleoplasm; mitochondrion; cytoplasm; nucleus; cytosol
Molecular Function: protein binding; m7G(5')pppN diphosphatase activity; RNA 7-methylguanosine cap binding
Biological Process: deadenylation-dependent decapping; negative regulation of programmed cell death; nuclear mRNA cis splicing, via U2-type spliceosome; gene expression; mRNA catabolic process, deadenylation-dependent decay
Disease: Al-raqad Syndrome
Research Articles on DCPS
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Product Notes
The DCPS dcps (Catalog #AAA9203071) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 165-193. The DCPS Antibody (Center) reacts with Human (Predicted Reactivity: Bovine, Mouse, Pig, Rat) and may cross-react with other species as described in the data sheet. AAA Biotech's DCPS can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA). WB~~1:1000. Researchers should empirically determine the suitability of the DCPS dcps for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "DCPS, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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