Typical Testing Data/Standard Curve (for reference only)
(Mouse GDNF PicoKine ELISA Kit standard curve )
Mouse GDNF ELISA Kit | GDNF elisa kit
Mouse GDNF PicoKine ELISA Kit
Typical Testing Data/Standard Curve (for reference only)
(Mouse GDNF PicoKine ELISA Kit standard curve )
Typical Testing Data/Standard Curve (for reference only)
(Mouse GDNF PicoKine ELISA Kit standard curve )
Immunohistochemistry (IHC)
(Applications: Detecting GDNFSample: Brain Tissue (Hippocampus)Detection: --"We used this kit and the BDNF kit, because we were looking at neurogenesis within the hippocampus. We used the ELISA to complement our immunohistochemistry. It was easy to optimize the kits and the instructions were extremely easy to follow. Additionally, the instructions do not include using samples from tissue homogenates, but we did and the plates came out great. This product was selected after speaking with a representative about it at a conference. I am extremely glad we decided to go with this kit. This is a great kit. The protocol was easy to follow and optimize. We will be using these kits again.")
Immunohistochemistry (IHC)
(Applications: Detecting GDNFSample: Brain Tissue (Hippocampus)Detection: --"We used this kit and the BDNF kit, because we were looking at neurogenesis within the hippocampus. We used the ELISA to complement our immunohistochemistry. It was easy to optimize the kits and the instructions were extremely easy to follow. Additionally, the instructions do not include using samples from tissue homogenates, but we did and the plates came out great. This product was selected after speaking with a representative about it at a conference. I am extremely glad we decided to go with this kit. This is a great kit. The protocol was easy to follow and optimize. We will be using these kits again.")
Background: Glial cell line-derived neurotrophic factor (GDNF) is a glycosylated, disulfide-bonded homodimer that is a distantly related member of the transforming growth factor-beta superfamily.1 GDNF, is a potent neurotrophic factor thatpromotes the survival of dopaminergic neurones in cultures including embryonic neuronal cultures.2 GDNF, inaddition to its potential role in the differentiation and survival of central nervous system neurons, has profound effects on kidney organogenesis and the development of the peripheral nervous system.3 GDNF may have utility inthe treatment of Parkinson's disease, which is marked by progressive degeneration of midbrain dopaminergic neurons.
NCBI and Uniprot Product Information
Uniprot Description
GDNF: Neurotrophic factor that enhances survival and morphological differentiation of dopaminergic neurons and increases their high-affinity dopamine uptake. Defects in GDNF may be a cause of Hirschsprung disease type 3 (HSCR3). In association with mutations of RET gene, defects in GDNF may be involved in Hirschsprung disease. This genetic disorder of neural crest development is characterized by the absence of intramural ganglion cells in the hindgut, often resulting in intestinal obstruction. Defects in GDNF are a cause of congenital central hypoventilation syndrome (CCHS); also known as congenital failure of autonomic control or Ondine curse. CCHS is a rare disorder characterized by abnormal control of respiration in the absence of neuromuscular or lung disease, or an identifiable brain stem lesion. A deficiency in autonomic control of respiration results in inadequate or negligible ventilatory and arousal responses to hypercapnia and hypoxemia. Belongs to the TGF-beta family. GDNF subfamily. 5 isoforms of the human protein are produced by alternative splicing.
Protein type: Secreted, signal peptide; Secreted
Cellular Component: extracellular space; extracellular region; receptor complex
Molecular Function: glial cell line-derived neurotrophic factor receptor binding; protein homodimerization activity; growth factor activity; transforming growth factor beta receptor binding
Biological Process: peristalsis; enteric nervous system development; neuron differentiation; sympathetic nervous system development; ureteric bud development; transforming growth factor beta receptor signaling pathway; induction of an organ; positive regulation of cell proliferation; response to wounding; postganglionic parasympathetic nervous system development; negative regulation of neuron apoptosis; postsynaptic membrane organization; neural crest cell migration; neurite development; nervous system development; mRNA stabilization; positive regulation of monooxygenase activity; regulation of dopamine uptake; peripheral nervous system development; cell proliferation; regulation of gene expression; ureteric bud branching; positive regulation of transcription from RNA polymerase II promoter; positive regulation of cell differentiation; metanephros development; transmembrane receptor protein tyrosine kinase signaling pathway
Research Articles on GDNF
Similar Products
Product Notes
The Mouse GDNF gdnf (Catalog #AAA176519) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA176519 ELISA Kit recognizes Mouse GDNF. It is sometimes possible for the material contained within the vial of "GDNF, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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