Typical Testing Data/Standard Curve (for reference only)
Mouse Glial cell line-derived neurotrophic factor ELISA Kit | Gdnf elisa kit
Mouse Glial cell line-derived neurotrophic factor ELISA Kit
Typical Testing Data/Standard Curve (for reference only)
Typical Testing Data/Standard Curve (for reference only)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a highly conserved neurotrophic factor. The recombinant form of this protein was shown to promote the survival and differentiation of dopaminergic neurons in culture, and was able to prevent apoptosis of motor neurons induced by axotomy. The encoded protein is processed to a mature secreted form that exists as a homodimer. The mature form of the protein is a ligand for the product of the RET (rearranged during transfection) protooncogene. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2015]
Uniprot Description
GDNF: Neurotrophic factor that enhances survival and morphological differentiation of dopaminergic neurons and increases their high-affinity dopamine uptake. Defects in GDNF may be a cause of Hirschsprung disease type 3 (HSCR3). In association with mutations of RET gene, defects in GDNF may be involved in Hirschsprung disease. This genetic disorder of neural crest development is characterized by the absence of intramural ganglion cells in the hindgut, often resulting in intestinal obstruction. Defects in GDNF are a cause of congenital central hypoventilation syndrome (CCHS); also known as congenital failure of autonomic control or Ondine curse. CCHS is a rare disorder characterized by abnormal control of respiration in the absence of neuromuscular or lung disease, or an identifiable brain stem lesion. A deficiency in autonomic control of respiration results in inadequate or negligible ventilatory and arousal responses to hypercapnia and hypoxemia. Belongs to the TGF-beta family. GDNF subfamily. 5 isoforms of the human protein are produced by alternative splicing.
Protein type: Secreted, signal peptide; Secreted
Cellular Component: extracellular region; extracellular space; receptor complex
Molecular Function: glial cell line-derived neurotrophic factor receptor binding; growth factor activity; protein homodimerization activity; transforming growth factor beta receptor binding
Biological Process: cell proliferation; enteric nervous system development; induction of an organ; metanephros development; mRNA stabilization; negative regulation of neuron apoptosis; nervous system development; neural crest cell migration; neurite development; neuron differentiation; peripheral nervous system development; peristalsis; positive regulation of cell differentiation; positive regulation of cell proliferation; positive regulation of monooxygenase activity; positive regulation of transcription from RNA polymerase II promoter; postganglionic parasympathetic nervous system development; postsynaptic membrane organization; regulation of dopamine uptake; regulation of gene expression; response to wounding; sympathetic nervous system development; transforming growth factor beta receptor signaling pathway; transmembrane receptor protein tyrosine kinase signaling pathway; ureteric bud branching; ureteric bud development
Research Articles on Gdnf
Similar Products
Product Notes
The Mouse Gdnf gdnf (Catalog #AAA2880804) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA2880804 ELISA Kit recognizes Mouse Gdnf. It is sometimes possible for the material contained within the vial of "Glial cell line-derived neurotrophic factor, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
