Mouse Follistatin (FS) ELISA Kit | FS elisa kit

Mouse Follistatin (FS) ELISA Kit

Cat. Num. AAA452500

• Gene Names: Fst; FS; AL033346
• Reactivity: Mouse
• Synonyms: Follistatin (FS); Mouse Follistatin (FS) ELISA Kit; FST; Activin-binding protein; FS elisa kit

• Reactivity: Mouse
• Sequence Length: 344

• Samples: Serum, plasma and other biological fluids.
• Assay Type: Competitive inhibition
• Detection Range: 3.125-200ng/mL
• Sensitivity: 0.95ng/mL
• Intra Assay: CV<10%
• Inter Assay: CV<12%
• Preparation and Storage: For unopened kit, all reagents should be kept according to the labels on vials. The TMB Substrate, Wash Buffer, Stop Solution should be stored at 4 degree C. All others should be stored at -20 degree C.

Typical Testing Data/Standard Curve (for reference only)

NCBI and Uniprot Product Information

• NCBI GI #: 672890584
• NCBI GeneID: 14313
• NCBI Accession #: NP_001288302.1
• NCBI GenBank Nucleotide #: NM_001301373.1
• UniProt Accession #: P47931; A6H6P0
• Molecular Weight: 37,866 Da
• NCBI Official Full Name: follistatin FST315
• NCBI Official Synonym Full Names: follistatin
• NCBI Official Symbol: Fst
• NCBI Official Synonym Symbols: FS; AL033346
• NCBI Protein Information: follistatin
• UniProt Protein Name: Follistatin
• Protein Family: Follistatin
• UniProt Gene Name: Fst
• UniProt Synonym Gene Names: FS

NCBI Description

The protein encoded by this gene binds to and negatively regulates activin, as well as other members of the transforming growth factor beta family, and acts to prevent uncontrolled cellular proliferation. This protein also contains a heparin-binding sequence. It is expressed in many of the tissues in which activin is synthesized and is thought to clear activin from the circulation by attachment to the cell surface. Alternative splicing results in multiple transcript variants that encode multiple protein isoforms, including FST315 and FST288, that differ at their C-terminus. Another isoform, FST303 is thought to be produced by proteolytic cleavage of FST315. These isoforms differ in their localization and in their ability to bind heparin. While FST315 is a circulating protein, FST288 is tissue-bound, and FST303 is gonad-specific. While deletion of all isoforms results in embryonic lethality, expression of just FST288 is sufficient for embryonic development, but the resultant mice have fertility defects. [provided by RefSeq, Aug 2014]

Uniprot Description

Binds directly to activin and functions as an activin antagonist. Specific inhibitor of the biosynthesis and secretion of pituitary follicle stimulating hormone (FSH).