Mouse Deoxyribonuclease-1 (DNaseI) ELISA Kit | DNaseI elisa kit

Mouse Deoxyribonuclease-1 (DNaseI) ELISA Kit

Cat. Num. AAA3806273

• Reactivity: Mouse
• Synonyms: Deoxyribonuclease-1 (DNaseI); Mouse Deoxyribonuclease-1 (DNaseI) ELISA Kit; DNaseI elisa kit

• Reactivity: Mouse
• Sequence Length: 282

• Sensitivity: 1 pg/mL
• Intra-assay Precision: Intra-assay CV is less than 15%.
• Inter-assay Precision: Inter-assay CV is less than 15%.

Typical Testing Data/Standard Curve (for reference only)

Related Product Information for DNaseI elisa kit

Intended Uses: This DNASE I ELISA kit is intended Laboratory for Research use only. The Stop Solution changes the color from blue to yellow and the intensity of the color is measured at 450 nm using a spectrophotometer. In order to measure the concentration of DNASE I in the sample, this DNASE I ELISA Kit includes a set of calibration standards. The calibration standards are assayed at the same time as the samples and allow the operator to produce a standard curve of Optical Density versus DNASE I concentration. The concentration of DNASE I in the samples is then determined by comparing the O.D. of the samples to the standard curve.

NCBI and Uniprot Product Information

• NCBI GI #: 21361254
• NCBI GenBank Nucleotide #: NP_005214.2
• UniProt Accession #: P24855
• NCBI Official Full Name: deoxyribonuclease-1
• UniProt Protein Name: Deoxyribonuclease-1
• UniProt Gene Name: DNASE1
• UniProt Synonym Gene Names: DNL1; DRNI; DNase I
• UniProt Entry Name: DNAS1_HUMAN

Uniprot Description

DNASE1: Among other functions, seems to be involved in cell death by apoptosis. Binds specifically to G-actin and blocks actin polymerization. Defects in DNASE1 are a cause of susceptibility to systemic lupus erythematosus (SLE). A chronic, inflammatory and often febrile multisystemic disorder of connective tissue. It affects principally the skin, joints, kidneys and serosal membranes. It is thought to represent a failure of the regulatory mechanisms of the autoimmune system. Belongs to the DNase I family.

Protein type: Deoxyribonuclease; Motility/polarity/chemotaxis; Secreted; Secreted, signal peptide; EC 3.1.21.1

Chromosomal Location of Human Ortholog: 16p13.3

Cellular Component: extracellular region; nuclear envelope; nucleus

Molecular Function: protein binding; deoxyribonuclease I activity; actin binding; endodeoxyribonuclease activity

Biological Process: apoptosis; DNA catabolic process, endonucleolytic

Disease: Systemic Lupus Erythematosus