Mouse CCAAT/Enhancer Binding Protein Beta (CEBPb) ELISA Kit | CEBPb elisa kit

Mouse CCAAT/Enhancer Binding Protein Beta (CEBPb) ELISA Kit

Cat. Num. AAA454962

• Gene Names: Cebpb; LAP; LIP; CRP2; NF-M; Nfil6; NF-IL6; IL-6DBP; C/EBPbeta
• Reactivity: Mouse
• Synonyms: CCAAT/Enhancer Binding Protein Beta (CEBPb); Mouse CCAAT/Enhancer Binding Protein Beta (CEBPb) ELISA Kit; CRP2 IL6DBP LAP NF-IL6 TCF5 C/EBP-Beta Liver-Enriched Transcriptional Activator Protein Nuclear Factor Of Interleukin 6 Interleukin 6-Dependent DNA-Binding Protein; CEBPb elisa kit

• Reactivity: Mouse
• Sequence Length: 275

• Samples: Tissue homogenates, cell lysates and other biological fluids.
• Assay Type: Sandwich
• Detection Range: 78.125-5000pg/mL
• Sensitivity: 33pg/mL
• Intra Assay: CV<10%
• Inter Assay: CV<12%
• Preparation and Storage: For unopened kit, all reagents should be kept according to the labels on vials. The TMB Substrate, Wash Buffer, Stop Solution should be stored at 4 degree C. All others should be stored at -20 degree C.

Typical Testing Data/Standard Curve (for reference only)

NCBI and Uniprot Product Information

• NCBI GI #: 567757569
• NCBI GeneID: 12608
• NCBI Accession #: NP_001274667.1
• NCBI GenBank Nucleotide #: NM_001287738.1
• UniProt Accession #: P28033
• Molecular Weight: 15,597 Da
• NCBI Official Full Name: CCAAT/enhancer-binding protein beta isoform b
• NCBI Official Synonym Full Names: CCAAT/enhancer binding protein (C/EBP), beta
• NCBI Official Symbol: Cebpb
• NCBI Official Synonym Symbols: LAP; LIP; CRP2; NF-M; Nfil6; NF-IL6; IL-6DBP; C/EBPbeta
• NCBI Protein Information: CCAAT/enhancer-binding protein beta
• UniProt Protein Name: CCAAT/enhancer-binding protein beta
• Protein Family: CCAAT/enhancer-binding protein
• UniProt Gene Name: Cebpb
• UniProt Synonym Gene Names: C/EBP beta; IL-6DBP; LAP

Uniprot Description

Important transcription factor regulating the expression of genes involved in immune and inflammatory responses (PubMed:16585579, PubMed:17911624, PubMed:18486321, PubMed:20111005). Plays also a significant role in adipogenesis, as well as in the gluconeogenic pathway, liver regeneration, and hematopoiesis (PubMed:9727068, PubMed:10635333, PubMed:17301242, PubMed:17601773, PubMed:19478079, PubMed:24061474, PubMed:24216764). The consensus recognition site is 5'-T[TG]NNGNAA[TG]-3'. Its functional capacity is governed by protein interactions and post-translational protein modifications. During early embryogenesis, plays essential and redundant functions with CEBPA (PubMed:15509779). Has a promitotic effect on many cell types such as hepatocytes and adipocytes but has an antiproliferative effect on T-cells by repressing MYC expression, facilitating differentiation along the T-helper 2 lineage (PubMed:9727068, PubMed:10635333, PubMed:16585579). Binds to regulatory regions of several acute-phase and cytokines genes and plays a role in the regulation of acute-phase reaction and inflammation. Plays also a role in intracellular bacteria killing (PubMed:17911624). During adipogenesis, is rapidly expressed and, after activation by phosphorylation, induces CEBPA and PPARG, which turn on the series of adipocyte genes that give rise to the adipocyte phenotype. The delayed transactivation of the CEBPA and PPARG genes by CEBPB appears necessary to allow mitotic clonal expansion and thereby progression of terminal differentiation (PubMed:15985551, PubMed:17301242, PubMed:17601773, PubMed:20194620). Essential for female reproduction because of a critical role in ovarian follicle development (PubMed:9303532). Restricts osteoclastogenesis (PubMed:19440205).