Mouse Anoctamin-10 (ANO10) ELISA Kit | ANO10 elisa kit
Mouse Anoctamin-10 (ANO10) ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the anoctamin family, which in mammals is comprised of 10 members. Anoctamin proteins are proposed to have eight transmembrane domains with both termini facing the cytoplasm and a C-terminal domain of unknown function. While some members have been characterized as calcium-activated chloride channels, this protein is reported to inhibit anion conductance. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Dec 2012]
Uniprot Description
ANO10: May act as a calcium-activated chloride channel. Defects in ANO10 are the cause of spinocerebellar ataxia autosomal recessive type 10 (SCAR10). Spinocerebellar ataxia is a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. SCAR10 is characterized by onset in the teenage or young adult years of gait and limb ataxia, dysarthria, and nystagmus associated with marked cerebellar atrophy on brain imaging. Belongs to the anoctamin family. 4 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral; Transporter; Transporter, ion channel; Membrane protein, multi-pass
Cellular Component: membrane; plasma membrane; integral to membrane; intracellular
Molecular Function: phospholipid scramblase activity; intracellular calcium activated chloride channel activity; calcium activated cation channel activity
Biological Process: chloride transport; cation transport
Research Articles on ANO10
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Product Notes
The Mouse ANO10 ano10 (Catalog #AAA7203526) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA7203526 ELISA Kit recognizes Mouse ANO10. It is sometimes possible for the material contained within the vial of "Anoctamin-10 (ANO10), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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