Testing Data
Mouse CD44 Antibody | anti-CD44 antibody
Mouse Anti-Human CD44-LE/AF
Testing Data
Testing Data
2. Krajewski AS, Howie S, O'Grady J, Biddlestone LR, Bellamy CO. Immunohistochemical staining of paraffin sections of lymphoid and epithelial tissues with workshop adhesion structure subpanel 10 (CD44) mAb. In: Schlossman SF, Boumsell L, Gilks W, Harlan JM, Kishimoto T, Morimoto C, et al, editors. Leukocyte Typing V: White Cell Differentiation Antigens. Oxford: Oxford University Press; 1995. p. 1740-2. (IHC-PS)
3. Anwar F, Wood BL. CD44H and CD44V6 expression in different subtypes of Hodgkin lymphoma. Mod Pathol. 2000;13:1121-7. (IHC-PS)
4. Štefanová I, Hilgert I, Bažil V, Angelisová P, Ho?ejší V. Reactivity of the non-lineage/NK panel antibodies with purified antigens CD45, CD43, CD44, and CD18, and three 'novel' antigens MEM-43, MEM-53, and MEM-102. In: Knapp W, Dörken B, Gilks WR, Rieber EP, Schmidt RE, Stein H, et al, editors. Leukocyte Typing IV: White Cell Differentiation Antigens. Oxford: Oxford University Press; 1989. p. 678-80. (WB)
5. Fukuda Y, Kurihara N, Imoto I, Yasui K, Yoshida M, Yanagihara K, et al. CD44 is a potential target of amplification within the 11p13 amplicon detected in gastric cancer cell lines. Genes Chromosomes Cancer. 2000;29:315-24. (WB, ICC)
6. Mathieu S, Gerolami R, Luis J, Carmona S, Kol O, Crescence L, et al. Introducing alpha(1,2)-linked fucose into hepatocarcinoma cells inhibits vasculogenesis and tumor growth. Int J Cancer. 2007;121:1680-9. (ICC)
7. Mackay CR, Maddox JF, Wijffels GL, Mackay IR, Walker ID. Characterization of a 95,000 molecule on sheep leucocytes homologous to murine Pgp-1 and human CD44. Immunology. 1988;65:93-9. (IP)
8. Stamenkovic I, Aruffo A, Amiot M, Seed B. The hematopoietic and epithelial forms of CD44 are distinct polypeptides with different adhesion potentials for hyaluronate-bearing cells. EMBO J. 1991;10:343-8. (IP, FC)
9. Bartolazzi A, Jackson D, Bennett K, Aruffo A, Dickinson R, Shields J, et al. Regulation of growth and dissemination of a human lymphoma by CD44 splice variants. J Cell Sci. 1995;108:1723-33. (IP, Depletion, FC)
10. Ruile P, Rank G, Rieber EP. mAb inhibiting the adherence of germinal centre B lymphocytes to follicular dendritic. In: Schlossman SF, Boumsell L, Gilks W, Harlan JM, Kishimoto T, Morimoto C, et al, editors. Leukocyte Typing V: White Cell Differentiation Antigens. Oxford: Oxford University Press; 1995. p. 1576-7. (Adhesion, Block)
11. Denning SM, Telen MJ, Hale LP, Liao HX, Haynes BF. CD44 and CD44R cluster report. In: Schlossman SF, Boumsell L, Gilks W, Harlan JM, Kishimoto T, Morimoto C, et al, editors. Leukocyte Typing V: White Cell Differentiation Antigens. Oxford: Oxford University Press; 1995. p. 1713-9. (Activ)
12. Takahashi K, Eto H, Tanabe KK. Involvement of CD44 in matrix metalloproteinase-2 regulation in human melanoma cells. Int J Cancer. 1999;80:387-95. (WB, Adhesion, Activ)
13. Murray D, Morrin M, McDonnell S. Increased invasion and expression of MMP-9 in human colorectal cell lines by a CD44-dependent mechanism. Anticancer Res. 2004;24:489-94. (Activ)
14. Chapman JR, Taylor CJ, Carter NP, Morris PJ. Comparison of non-lineage antibodies with cytotoxic autoreactive antibodies in haemodialysis patients. In: McMichael AJ, Beverley PC, Cobbold S, Crumpton MJ, Gilks W, Gotch FM, et al, editors. Leukocyte Typing III: White Cell Differentiation Antigens. Oxford: Oxford University Press; 1987. p. 826-8. (CMDC)
15. Dalchau R, Flanagan BF, Allen AK, Daar AS, Fabre JW. Chemical composition and tissue distribution of the human CD44 glycoprotein. In: Knapp W, Dörken B, Gilks WR, Rieber EP, Schmidt RE, Stein H, et al, editors. Leukocyte Typing IV: White Cell Differentiation Antigens. Oxford: Oxford University Press; 1989. p. 622-5. (Purification, FC)
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is a cell-surface glycoprotein involved in cell-cell interactions, cell adhesion and migration. It is a receptor for hyaluronic acid (HA) and can also interact with other ligands, such as osteopontin, collagens, and matrix metalloproteinases (MMPs). This protein participates in a wide variety of cellular functions including lymphocyte activation, recirculation and homing, hematopoiesis, and tumor metastasis. Transcripts for this gene undergo complex alternative splicing that results in many functionally distinct isoforms, however, the full length nature of some of these variants has not been determined. Alternative splicing is the basis for the structural and functional diversity of this protein, and may be related to tumor metastasis. [provided by RefSeq, Jul 2008]
Uniprot Description
CD44: Receptor for hyaluronic acid (HA). Mediates cell-cell and cell-matrix interactions through its affinity for HA, and possibly also through its affinity for other ligands such as osteopontin, collagens, and matrix metalloproteinases (MMPs). Adhesion with HA plays an important role in cell migration, tumor growth and progression. Also involved in lymphocyte activation, recirculation and homing, and in hematopoiesis. Altered expression or dysfunction causes numerous pathogenic phenotypes. Great protein heterogeneity due to numerous alternative splicing and post-translational modification events. Interacts with PKN2. Interacts with HA, as well as other glycosaminoglycans, collagen, laminin, and fibronectin via its N-terminal segment. Interacts with ANK, the ERM proteins (VIL2, RDX and MSN), and NF2 via its C-terminal segment. Isoform 10 (epithelial isoform) is expressed by cells of epithelium and highly expressed by carcinomas. Expression is repressed in neuroblastoma cells. 19 isoforms of the human protein are produced by alternative splicing.
Protein type: Cell adhesion; Membrane protein, integral; Receptor, misc.; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 11p13
Cellular Component: cell surface; cytoplasm; focal adhesion; Golgi apparatus; integral to plasma membrane; plasma membrane
Molecular Function: collagen binding; hematopoietin/interferon-class (D200-domain) cytokine receptor activity; hyaluronic acid binding; hyalurononglucosaminidase activity; protein binding
Biological Process: cartilage development; cell-cell adhesion; cell-matrix adhesion; extracellular matrix disassembly; extracellular matrix organization and biogenesis; hyaluronan catabolic process; leukocyte migration; negative regulation of apoptosis; negative regulation of caspase activity; negative regulation of DNA damage response, signal transduction by p53 class mediator; positive regulation of heterotypic cell-cell adhesion; positive regulation of peptidyl-serine phosphorylation; positive regulation of peptidyl-tyrosine phosphorylation
Disease: Blood Group, Indian System
Research Articles on CD44
Similar Products
Product Notes
The CD44 cd44 (Catalog #AAA670608) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. AAA Biotech's CD44 can be used in a range of immunoassay formats including, but not limited to, Flow Cytometry (FC/FACS), Immunohistochemistry (IHC) Formalin/Paraffin, Immunocytochemistry (ICC), Immunoprecipitation (IP), Immunoblot (IB), Complement Mediated Cell Depletion, Depletion, Adhesion, Activation, Blocking (BL), Purification. Flow Cytometry - Quality tested; Immunohistochemistry-Frozen Sections - Reported in literature; Immunohistochemistry-Paraffin Sections - Reported in literature; Immunocytochemistry - Reported in literature; Immunoprecipitation - Reported in literature; Immunoblotting - Reported in literature; Complement Mediated Cell Depletion - Reported in literature; Depletion - Reported in literature; Adhesion - Reported in literature; Activation - Reported in literature; Blocking - Reported in literature; Purification - Reported in literature. Researchers should empirically determine the suitability of the CD44 cd44 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "CD44, Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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