IL3 active protein

IL3 protein (Mouse)

Cat. Num. AAA538202

• Gene Names: IL3; IL-3; MCGF; MULTI-CSF
• Applications: User optimized
• Purity: > 98% pure
• Synonyms: IL3; IL3 protein (Mouse); IL-3 protein; IL 3; Interleukin 3 protein; Multi-CSF protein; HCGF protein; IL-3; IL 3 protein; P-cell stimulation factor protein; Mast cell growth factor protein; MCGF protein; IL3 active protein

• Host: Mouse
• Purity/Purification: > 98% pure
• Form/Format: Supplied lyophilized with no additives. Reconstitute in water to a concentration of 0.1-1.0 mg/ml. Keep pH below 5.0.
• Sequence: Region of IL3 protein corresponding to amino acids MDTHRLTRTL NCSSIVKEII GKLPEPELKT DDEGPSLRNK SFRRVNLSKF VESQGEVDPE DRYVIKSNLQ KLNCCLPTSA NDSALPGVFI RDLDDFRKKL RFYMVHLNDL ETVLTSRPPQ PASGSVSPNR GTVEC.
• Sequence Length: 152

• Applicable Applications for IL3 active protein: User optimized
• Protein Type: Recombinant
• Biological Significance: IL3 is a hematopoietic growth factor that promotes the survival, differentiation and proliferation of committed progenitor cells of the megakaryocyte, granulocyte-macrophage, erythroid, eosinophil, basophil and mast cell lineages. Produced by T cells, mast cells and eosinophils, IL3 enhances thrombopoieses, phagocytosis, and antibody-mediated cellular cytotoxicity. Its ability to activate monocytes suggests that IL3 may have additional immunoregulatory roles. Many of the IL3 activities depend upon co-stimulation with other cytokines. IL3 is species-specific, variably glycosylated cytokine.
• Bioactivity: The ED50 as determined by the dose-dependent stimulation of the proliferation of Mouse M-NFS-60 cells is 2 x 10^7 units/mg.
• Endotoxin Levels: Endotoxin level is less than 0.1 ng per ug (1 EU/ug).
• Expression System: E Coli
• Preparation and Storage: Store at 4 degree C until reconstitution. Following reconstitution aliquot and freeze at -20 degree C for long term storage. Avoid repeated freeze/thaw cycles.

Related Product Information for IL3 active protein

Purified recombinant Mouse IL3 protein

Product Categories/Family for IL3 active protein

Cytokines & Growth Factors

NCBI and Uniprot Product Information

• NCBI GI #: 47481003
• NCBI GeneID: 3562
• UniProt Accession #: P08700; Q6GS87
• Molecular Weight: 15.1 kDa
• NCBI Official Full Name: Interleukin 3,
• NCBI Official Synonym Full Names: interleukin 3
• NCBI Official Symbol: IL3
• NCBI Official Synonym Symbols: IL-3; MCGF; MULTI-CSF
• NCBI Protein Information: interleukin-3
• UniProt Protein Name: Interleukin-3
• Protein Family: Interleukin
• UniProt Gene Name: IL3
• UniProt Synonym Gene Names: IL-3; MCGF
• UniProt Entry Name: IL3_HUMAN

NCBI Description

The protein encoded by this gene is a potent growth promoting cytokine. This cytokine is capable of supporting the proliferation of a broad range of hematopoietic cell types. It is involved in a variety of cell activities such as cell growth, differentiation and apoptosis. This cytokine has been shown to also possess neurotrophic activity, and it may be associated with neurologic disorders. [provided by RefSeq, Jul 2008]

Uniprot Description

IL3: Granulocyte/macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages. Belongs to the IL-3 family.

Protein type: Secreted; Apoptosis; Secreted, signal peptide; Cell cycle regulation; Oncoprotein; Cytokine

Chromosomal Location of Human Ortholog: 5q31.1

Cellular Component: extracellular space; extracellular region

Molecular Function: interleukin-3 receptor binding; growth factor activity; cytokine activity

Biological Process: nervous system development; positive regulation of peptidyl-tyrosine phosphorylation; cell-cell signaling; positive regulation of tyrosine phosphorylation of Stat5 protein; embryonic hemopoiesis; cytokine and chemokine mediated signaling pathway; positive regulation of cell proliferation; immune response; positive regulation of myeloid leukocyte differentiation; positive regulation of DNA replication