Exodus 2 active protein

Exodus 2 protein (Mouse)

Cat. Num. AAA539574

• Gene Names: CCL21; ECL; SLC; CKb9; TCA4; 6Ckine; SCYA21
• Applications: User optimized
• Purity: > 98% pure
• Synonyms: Exodus 2; Exodus 2 protein (Mouse); SLC protein; Exodus-2 protein; 6Ckine protein; Exodus 2 protein; Exodus-2; CCL21 protein; Exodus 2 active protein

• Host: Mouse
• Purity/Purification: > 98% pure
• Form/Format: Supplied as a lyophilized powder.
• Sequence: Region of Exodus 2 protein corresponding to amino acids SDGGGQDCCL KYSQKKIPYS IVRGYRKQEP SLGCPIPAIL FLPRKHSKPE LCANPEEGWV QNLMRRLDQP PAPGKQSPGC RKNRGTSKSG KKGKGSKGCK RTEQTQPSRG.
• Sequence Length: 134

• Applicable Applications for Exodus 2 active protein: User optimized
• Protein Type: Recombinant
• Biological Significance: Exodus-2 is a CC chemokine that can signal through the CCR7 receptor. It is expressed in lymph nodes of certain endothelial cells, and in the spleen and appendix. Exodus-2 chemoattracts T and B lymphocytes and inhibits hematopoiesis. Exodus-2 contains six cysteine residues, including the four conserved cysteines present in CC chemokines.
• Bioactivity: Determined by its ability to chemoattract total Mouse T cell population using a concentration range of 10.0-100.0 ng/ml.
• Endotoxin Levels: Endotoxin level is less than 0.1 ng per ug (1 EU/ug).
• Expression System: E Coli
• Preparation and Storage: Store at 4 degree C until reconstitution. Following reconstitution aliquot and freeze at -20 degree C for long term storage. Avoid repeated freeze/thaw cycles.

Related Product Information for Exodus 2 active protein

Purified recombinant Mouse Exodus 2 protein

Product Categories/Family for Exodus 2 active protein

Cytokines & Growth Factors

NCBI and Uniprot Product Information

• NCBI GI #: 4506835
• NCBI GeneID: 6366
• NCBI Accession #: NP_002980.1
• NCBI GenBank Nucleotide #: NM_002989.2
• UniProt Accession #: O00585
• Molecular Weight: 12 kDa
• NCBI Official Full Name: C-C motif chemokine 21
• NCBI Official Synonym Full Names: chemokine (C-C motif) ligand 21
• NCBI Official Symbol: CCL21
• NCBI Official Synonym Symbols: ECL; SLC; CKb9; TCA4; 6Ckine; SCYA21
• NCBI Protein Information: C-C motif chemokine 21
• UniProt Protein Name: C-C motif chemokine 21
• UniProt Gene Name: CCL21
• UniProt Synonym Gene Names: SCYA21; SLC
• UniProt Entry Name: CCL21_HUMAN

NCBI Description

This antimicrobial gene is one of several CC cytokine genes clustered on the p-arm of chromosome 9. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. Similar to other chemokines the protein encoded by this gene inhibits hemopoiesis and stimulates chemotaxis. This protein is chemotactic in vitro for thymocytes and activated T cells, but not for B cells, macrophages, or neutrophils. The cytokine encoded by this gene may also play a role in mediating homing of lymphocytes to secondary lymphoid organs. It is a high affinity functional ligand for chemokine receptor 7 that is expressed on T and B lymphocytes and a known receptor for another member of the cytokine family (small inducible cytokine A19). [provided by RefSeq, Sep 2014]

Uniprot Description

CCL21: Inhibits hemopoiesis and stimulates chemotaxis. Chemotactic in vitro for thymocytes and activated T-cells, but not for B-cells, macrophages, or neutrophils. Shows preferential activity towards naive T-cells. May play a role in mediating homing of lymphocytes to secondary lymphoid organs. Belongs to the intercrine beta (chemokine CC) family.

Protein type: Chemokine; Secreted; Secreted, signal peptide; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 9p13

Cellular Component: extracellular space; extracellular region

Molecular Function: chemokine receptor binding; chemokine activity; CCR7 chemokine receptor binding

Biological Process: positive regulation of filopodium formation; positive regulation of I-kappaB kinase/NF-kappaB cascade; formation of immunological synapse; positive regulation of chemotaxis; positive regulation of dendritic cell antigen processing and presentation; cell maturation; positive regulation of JNK cascade; positive regulation of cell adhesion mediated by integrin; positive regulation of phosphoinositide 3-kinase activity; positive regulation of receptor-mediated endocytosis; G-protein coupled receptor protein signaling pathway; positive regulation of protein kinase B signaling cascade; positive regulation of pseudopodium formation; positive regulation of actin filament polymerization; cell-cell signaling; release of sequestered calcium ion into cytosol; positive regulation of protein kinase activity; T cell costimulation; ruffle organization and biogenesis; dendritic cell chemotaxis; immune response; establishment of T cell polarity; inflammatory response; positive regulation of cell-matrix adhesion