Mouse anti-Human ZAP70 Monoclonal Antibody | anti-ZAP70 antibody

Anti-ZAP70

Cat. Num. AAA516302

• Reactivity: Human
• Applications: Western Blot
• Purity: Affinity chromatography
• Synonyms: ZAP70; Monoclonal Antibody; Anti-ZAP70; anti-ZAP70 antibody

• Host: Mouse
• Reactivity: Human
• Clonality: Monoclonal
• Isotype: Mouse, IgG
• Specificity: Recognizes the ZAP70 protein
• Purity/Purification: Affinity chromatography
• Form/Format: PBS, pH7.4 with 0.02% sodium azide.

• Applicable Applications for anti-ZAP70 antibody: Western Blot (WB)
• Immunogen: Recombinant Human ZAP70
• Preparation and Storage: Store at 4 degree C (add 0.1% NaN3) for several months, and at -20 degree C for longer periods. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.; 1 year at -20 degree C from date of shipment

Related Product Information for anti-ZAP70 antibody

ZAP70 is a non-receptor protein tyrosine kinase (part of the Syk/Zap70 family) that is involved in signaling by the T-cell antigen receptor (TCR). Ligation of the TCR/CD3 receptor in Jurkat T-cells induces phosphoprotein complexes which contain ZAP70 (1). TCR zeta chains are initially phosphorylated by p56Lck that lead to the recruitment of ZAP70 via its SH2 domain. ZAP70 in turn phosphorylates other proteins in the TCR-phosphoprotein complex. One of the natural substrates for ZAP70 is the zeta-chain dimer of the TCR/CD3 complex (2).

Product Categories/Family for anti-ZAP70 antibody

Primary Antibodies; Cancer; Cytoplasmic Tyrosine Kinases; Inflammation; NfkB Pathway

References

1. Duplay, P. et al: p56lck interacts via its src homology 2 domain with the ZAP-70 kinase. J Exp Med. 1994 Apr 1;179(4):1163-72.
2. Chan, A C. et al: Differential expression of ZAP-70 and Syk protein tyrosine kinases, and the role of this family of protein tyrosine kinases in TCR signaling. J Immunol. 1994 May 15;152(10):4758-66.