Rabbit anti-Human XPNPEP2  Monoclonal Antibody | anti-XPNPEP2  antibody

Rabbit anti Human XPNPEP2  Monoclonal Antibody

Cat. Num. AAA2544309

• Gene Names: XPNPEP2; APP2; AEACEI
• Reactivity: Human
• Applications: ELISA
• Synonyms: XPNPEP2 ; Monoclonal Antibody; Rabbit anti Human XPNPEP2 Monoclonal Antibody; anti-XPNPEP2 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Monoclonal
• Isotype: IgG
• Sequence Length: 674

• Applicable Applications for anti-XPNPEP2 antibody: ELISA (EIA)
• Application Notes: ELISA: 0.1-0.2 mug/mL. This antibody can be used at 0.1-0.2 mug/mL with the appropriate secondary reagents to detect Human XPNPEP2. The detection limit for Human XPNPEP2 is approximately 0.0049 ng/well.
• Immunogen: Recombinant Human XPNPEP2 protein
• Buffer: 0.2 mum filtered solution in PBS with 5% trehalose
• Preparation and Storage: This antibody can be stored at 2 degree C- 8 degree C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 degree C to -80 degree C. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.

Related Product Information for anti-XPNPEP2  antibody

Aminopeptidase P (APP) is a hydrolase specific for N-terminal imido bonds, which are common to several collagen degradation products, neuropeptides, vasoactive peptides, and cytokines. A membrane-bound and soluble form of this enzyme (XPNPEP2) have been identified as products of two separate genes. XPNPEP2, the X-linked gene that encodes membranous aminopeptidase P (APP), has been reported to associate with APP activity. The membrane aminopeptidase P (XPNPEP2) is largely limited in distribution to endothelia and brush border epithelia. APP and XPNPEP2 contain homologous blocks of sequence common to members of the "pita bread-fold" protein family, of which Escherichia coli methionine aminopeptidase is the prototype. The C-2399A variant in XPNPEP2 is associated with reduced APP activity and a higher incidence of AE-ACEi. XPNPEP2 mRNA was detected in fibroblasts that carry the translocation, suggesting that this gene at least partially escapes X inactivation. XPNPEP2 is a candidate gene for premature ovarian failure (POF).

NCBI and Uniprot Product Information

• NCBI GI #: 93141226
• NCBI GeneID: 7512
• NCBI GenBank Nucleotide #: NM_003399.5
• Molecular Weight: 75,625 Da
• NCBI Official Full Name: xaa-Pro aminopeptidase 2
• NCBI Official Synonym Full Names: X-prolyl aminopeptidase 2
• NCBI Official Symbol: XPNPEP2
• NCBI Official Synonym Symbols: APP2; AEACEI
• NCBI Protein Information: xaa-Pro aminopeptidase 2
• UniProt Protein Name: Xaa-Pro aminopeptidase 2
• UniProt Gene Name: XPNPEP2
• UniProt Synonym Gene Names: Membrane-bound APP; Membrane-bound AmP; mAmP
• UniProt Entry Name: XPP2_HUMAN

NCBI Description

Aminopeptidase P is a hydrolase specific for N-terminal imido bonds, which are common to several collagen degradation products, neuropeptides, vasoactive peptides, and cytokines. Structurally, the enzyme is a member of the 'pita bread fold' family and occurs in mammalian tissues in both soluble and GPI-anchored membrane-bound forms. A membrane-bound and soluble form of this enzyme have been identified as products of two separate genes. [provided by RefSeq, Jul 2008]

Uniprot Description

XPNPEP2: A metalloprotease that may play a role in the inflammatory process and other reactions produced in response to injury or infection. May also play a role in the metabolism of the vasodilator bradykinin. Belongs to the peptidase M24B family.

Protein type: EC 3.4.11.9; Membrane protein, GPI anchor; Protease

Chromosomal Location of Human Ortholog: Xq25

Cellular Component: membrane

Molecular Function: aminopeptidase activity

Disease: Angioedema Induced By Ace Inhibitors, Susceptibility To