Mouse anti-Human TRPC4AP Monoclonal Antibody | anti-TRPC4AP antibody

TRPC4AP Mouse Monoclonal

Cat. Num. AAA7605250

• Gene Names: TRPC4AP; TRUSS; TRRP4AP; PPP1R158; C20orf188
• Reactivity: Human
• Applications: ELISA, Western Blot, Immunohistochemistry
• Purity: >=95% as determined by SDS-PAGE; Protein A+G purification
• Synonyms: TRPC4AP; Monoclonal Antibody; TRPC4AP Mouse Monoclonal; anti-TRPC4AP antibody

• Host: Mouse
• Reactivity: Human
• Clonality: Monoclonal
• Isotype: IgG1
• Purity/Purification: >=95% as determined by SDS-PAGE; Protein A+G purification
• Form/Format: Liquid
• Sequence Length: 263

• Applicable Applications for anti-TRPC4AP antibody: ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
• Immunogen: Transient receptor potential cation channel, subfamily C, member 4 associated protein
• Preparation and Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20 degree C for 24 months (Avoid repeated freeze / thaw cycles.)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded human breast cancer slide using MBS7605250 (TRPC4AP Antibody) at dilution of 1:50)

Western Blot (WB)

(human heart tissue were subjected to SDS PAGE followed by western blot with MBS7605250 (TRPC4AP antibody) at dilution of 1:500)

NCBI and Uniprot Product Information

• NCBI GI #: 39645211
• NCBI GeneID: 26133
• Molecular Weight: 90,043 Da
• NCBI Official Full Name: TRPC4AP protein, partial
• NCBI Official Synonym Full Names: transient receptor potential cation channel subfamily C member 4 associated protein
• NCBI Official Symbol: TRPC4AP
• NCBI Official Synonym Symbols: TRUSS; TRRP4AP; PPP1R158; C20orf188
• NCBI Protein Information: short transient receptor potential channel 4-associated protein
• UniProt Protein Name: Short transient receptor potential channel 4-associated protein
• Protein Family: Short transient receptor potential channel 4-associated protein
• UniProt Gene Name: TRPC4AP
• UniProt Synonym Gene Names: C20orf188; TRRP4AP; Trp4-associated protein; Trpc4-associated protein; Protein TRUSS
• UniProt Entry Name: TP4AP_HUMAN

Uniprot Description

TRPC4AP: Substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for cell cycle control. The DCX(TRUSS) complex specifically mediates the polyubiquitination and subsequent degradation of MYC. Also participates in the activation of NFKB1 in response to ligation of TNFRSF1A, possibly by linking TNFRSF1A to the IKK signalosome. Involved in JNK activation via its interaction with TRAF2. Also involved in elevation of endoplasmic reticulum Ca(2+) storage reduction in response to CHRM1. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Adaptor/scaffold

Chromosomal Location of Human Ortholog: 20q11.22

Cellular Component: plasma membrane

Molecular Function: calcium channel activity; phosphatase binding; protein binding

Biological Process: protein ubiquitination; ubiquitin-dependent protein catabolic process