Mouse anti-Human TROP-2 Monoclonal Antibody | anti-TACSTD2 antibody
TROP-2 (Tumor-associated Calcium Signal Transducer 2, ACSTD2, GA733 Tumor Associated Antigen, Epithelial Glycoprotein-1, EGP-1) (Carboxyfluorescein)
Gene Names
TACSTD2; EGP1; GP50; M1S1; EGP-1; TROP2; GA7331; GA733-1
Reactivity
Human
Applications
Flow Cytometry, Functional Assay
Purity
Affinity PurifiedPurified by Protein G affinity chromatography.
Synonyms
TROP-2; Monoclonal Antibody; TROP-2 (Tumor-associated Calcium Signal Transducer 2; ACSTD2; GA733 Tumor Associated Antigen; Epithelial Glycoprotein-1; EGP-1) (Carboxyfluorescein); Anti -TROP-2 (Tumor-associated Calcium Signal Transducer 2; anti-TACSTD2 antibody
Host
Mouse
Reactivity
Human
Clonality
Monoclonal
Isotype
IgG2a
Clone Number
9H189
Specificity
Recognizes human TROP-2.
Purity/Purification
Affinity Purified
Purified by Protein G affinity chromatography.
Purified by Protein G affinity chromatography.
Form/Format
Supplied as a liquid in saline containing up to 0.5% BSA and 0.1% sodium azide. Conjugated to Carboxyfluorescein (CFS) fluorochrome.
Applicable Applications for anti-TACSTD2 antibody
Flow Cytometry (FC/FACS)
Application Notes
Suitable for Flow Cytometry. Designed to quantitatively determine the percentage of cells, bearing TROP-2 within a population and qualitatively determine the density of TROP-2 on cell surfaces by flow cytometry.
Dilution: Flow Cytometry: 10ul is added to1-2.5x10e5 cells.
Dilution: Flow Cytometry: 10ul is added to1-2.5x10e5 cells.
Immunogen
NS0-derived, recombinant human TROP-2 extracellular domain, aa 27-274; P09758.
Hybridoma
Mouse myeloma with B cells obtained from a mouse immunized with purified, NS0-derived, recombinant human TROP-2 extracellular domain (rhTROP-2; aa 27-274; Accession # P09758).
Preparation and Storage
Lyophilized samples are stable for twelve months from date of receipt when stored at -20 degree C to -70 degree C. Upon reconstitution, the antibody can be stored at 2 degree -8 degree C for 1 month without detectable loss of activity. Reconstituted antibody can also be aliquotted and stored frozen at -20 degree C to -70 degree C in a manual defrost freezer for six months without detectable loss of activity. Avoid repeated freeze-thaw cycles.
Related Product Information for anti-TACSTD2 antibody
TROP-2, also named tumor-associated calcium signal transducer 2 (TACSTD2), GA733 tumor associated antigen, and epithelial glycoprotein-1 (EGP-1), is a type I transmembrane protein highly expressed in carcinomas.
Cell surface expression of TROP-2 is determined by flow cytometry using 488 nm wavelength excitation and monitoring emitted fluorescence with a detector optimized to collect peak emissions at 515-545 nm.
Cell surface expression of TROP-2 is determined by flow cytometry using 488 nm wavelength excitation and monitoring emitted fluorescence with a detector optimized to collect peak emissions at 515-545 nm.
Product Categories/Family for anti-TACSTD2 antibody
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
35,709 Da
NCBI Official Full Name
tumor-associated calcium signal transducer 2
NCBI Official Synonym Full Names
tumor-associated calcium signal transducer 2
NCBI Official Symbol
TACSTD2
NCBI Official Synonym Symbols
EGP1; GP50; M1S1; EGP-1; TROP2; GA7331; GA733-1
NCBI Protein Information
tumor-associated calcium signal transducer 2; epithelial glycoprotein-1; cell surface glycoprotein TROP2; cell surface glycoprotein Trop-2; pancreatic carcinoma marker protein GA7331; pancreatic carcinoma marker protein GA733-1; gastrointestinal tumor-associated antigen GA7331; membrane component chromosome 1 surface marker 1; membrane component, chromosome 1, surface marker 1; 40kD glycoprotein, identified by monoclonal antibody GA733
UniProt Protein Name
Tumor-associated calcium signal transducer 2
Protein Family
UniProt Gene Name
TACSTD2
UniProt Synonym Gene Names
GA733-1; M1S1; TROP2
UniProt Entry Name
TACD2_HUMAN
NCBI Description
This intronless gene encodes a carcinoma-associated antigen. This antigen is a cell surface receptor that transduces calcium signals. Mutations of this gene have been associated with gelatinous drop-like corneal dystrophy.[provided by RefSeq, Dec 2009]
Uniprot Description
TACSTD2: May function as a growth factor receptor. Defects in TACSTD2 are the cause of gelatinous drop-like corneal dystrophy (GDLD); also known as lattice corneal dystrophy type III. GDLD is an autosomal recessive disorder characterized by grayish corneal amyloid deposits that cause severe visual impairment. Belongs to the EPCAM family.
Protein type: Membrane protein, integral; Receptor, misc.
Chromosomal Location of Human Ortholog: 1p32
Cellular Component: extracellular space; membrane; integral to plasma membrane; basal plasma membrane; nucleus; cytosol; lateral plasma membrane
Molecular Function: protein binding; receptor activity
Biological Process: cell proliferation; negative regulation of stress fiber formation; cell surface receptor linked signal transduction; visual perception; regulation of epithelial cell proliferation
Disease: Corneal Dystrophy, Gelatinous Drop-like
Research Articles on TACSTD2
Similar Products
Product Notes
The TACSTD2 tacstd2 (Catalog #AAA608186) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The TROP-2 (Tumor-associated Calcium Signal Transducer 2, ACSTD2, GA733 Tumor Associated Antigen, Epithelial Glycoprotein-1, EGP-1) (Carboxyfluorescein) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's TROP-2 can be used in a range of immunoassay formats including, but not limited to, Flow Cytometry (FC/FACS). Suitable for Flow Cytometry. Designed to quantitatively determine the percentage of cells, bearing TROP-2 within a population and qualitatively determine the density of TROP-2 on cell surfaces by flow cytometry. Dilution: Flow Cytometry: 10ul is added to1-2.5x10e5 cells. Researchers should empirically determine the suitability of the TACSTD2 tacstd2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "TROP-2, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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