Mouse anti-Human Thyroid Hormone Receptor Interactor 13 Monoclonal Antibody | anti-TRIP13 antibody

Thyroid Hormone Receptor Interactor 13 (TRIP13)

Cat. Num. AAA600901

• Gene Names: TRIP13; 16E1BP
• Reactivity: Human
• Applications: Western Blot
• Purity: Affinity Purified; Purified by Protein G affinity chromatography.
• Synonyms: Thyroid Hormone Receptor Interactor 13; Monoclonal Antibody; Thyroid Hormone Receptor Interactor 13 (TRIP13); Anti -Thyroid Hormone Receptor Interactor 13 (TRIP13); anti-TRIP13 antibody

• Host: Mouse
• Reactivity: Human
• Clonality: Monoclonal
• Isotype: IgG2a
• Clone Number: 8C329
• Specificity: Recognizes human Thyroid Hormone Receptor Interactor 13.
• Purity/Purification: Affinity Purified; Purified by Protein G affinity chromatography.
• Form/Format: Supplied as a sterile-filtered liquid in PBS, pH 7.4, 1% BSA, 0.05% sodium azide.

• Applicable Applications for anti-TRIP13 antibody: Western Blot (WB)
• Application Notes: Suitable for use in Western Blotting.; Dilution: Western Blotting: 1:1000-1:2000
• Immunogen: Partial sequence of recombinant full-length protein to human Thyroid Hormone Receptor Interactor 13
• Preparation and Storage: May be stored at 4 degree C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile 40-50% glycerol, aliquot and store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Testing Data

Western Blot (WB)

(Detection of human TRIP13 by Western blot. Samples: Whole cell lysate (25ug) from HT-1080 cells. Predicted molecular weight: 48 kD)

Product Categories/Family for anti-TRIP13 antibody

Antibodies; Abs to Binding Proteins

NCBI and Uniprot Product Information

• NCBI GI #: 17939490
• NCBI GeneID: 9319
• UniProt Accession #: Q15645; O15324; C9K0T3; D3DTC0
• Molecular Weight: 48,551 Da
• NCBI Official Full Name: Thyroid hormone receptor interactor 13
• NCBI Official Synonym Full Names: thyroid hormone receptor interactor 13
• NCBI Official Symbol: TRIP13
• NCBI Official Synonym Symbols: 16E1BP
• NCBI Protein Information: pachytene checkpoint protein 2 homolog; 16E1-BP; TRIP-13; OTTHUMP00000115407; OTTHUMP00000221361; TR-interacting protein 13; HPV16 E1 protein binding protein; HPV16 E1 protein-binding protein; thyroid receptor interacting protein 13; thyroid receptor-interacting protein 13; human papillomavirus type 16 E1 protein-binding protein
• UniProt Protein Name: Pachytene checkpoint protein 2 homolog
• UniProt Gene Name: TRIP13
• UniProt Synonym Gene Names: PCH2
• UniProt Entry Name: PCH2_HUMAN

NCBI Description

This gene encodes a protein that interacts with thyroid hormone receptors, also known as hormone-dependent transcription factors. The gene product interacts specifically with the ligand binding domain. This gene is one of several that may play a role in early-stage non-small cell lung cancer. [provided by RefSeq]

Uniprot Description

TRIP13: Plays a key role in chromosome recombination and chromosome structure development during meiosis. Required at early steps in meiotic recombination that leads to non-crossovers pathways. Also needed for efficient completion of homologous synapsis by influencing crossover distribution along the chromosomes affecting both crossovers and non-crossovers pathways. Also required for development of higher-order chromosome structures and is needed for synaptonemal-complex formation. In males, required for efficient synapsis of the sex chromosomes and for sex body formation. Promotes early steps of the DNA double- strand breaks (DSBs) repair process upstream of the assembly of RAD51 complexes. Required for depletion of HORMAD1 and HORMAD2 from synapsed chromosomes. Belongs to the AAA ATPase family. PCH2 subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Nuclear receptor co-regulator; Transcription, coactivator/corepressor

Chromosomal Location of Human Ortholog: 5p15.33

Cellular Component: male germ cell nucleus; nucleus

Molecular Function: identical protein binding; protein binding; transcription cofactor activity; ATP binding

Biological Process: oogenesis; transcription from RNA polymerase II promoter; synaptonemal complex assembly; male meiosis I; double-strand break repair; meiotic recombination; spermatogenesis; oocyte maturation; spermatid development; female meiosis I