Thymidine Phosphorylase Monoclonal Antibody | anti-Tymp antibody

Anti - Thymidine Phosphorylase (TYMP, ECGF1, Gliostatin, hPD-ECGF, MNGIE, PDECGF, PD-ECGF, Platelet-derived endothelial cell growth factor, TdRPase, TP)

Cat. Num. AAA601382

• Gene Names: Tymp; Ecgf1; PDECGF; Pdgfec; PD-ECGF; 2900072D10Rik
• Reactivity: Human, Mouse, Rat
• Applications: Western Blot
• Purity: Purified by immunoaffinity chromatography.
• Synonyms: Thymidine Phosphorylase; Monoclonal Antibody; Anti - Thymidine Phosphorylase (TYMP; ECGF1; Gliostatin; hPD-ECGF; MNGIE; PDECGF; PD-ECGF; Platelet-derived endothelial cell growth factor; TdRPase; TP); Thymidine Phosphorylase (TYMP; anti-Tymp antibody

• Host: Host: Mouse; Source: Human
• Reactivity: Human, Mouse, Rat
• Clonality: Monoclonal
• Isotype: IgG1
• Clone Number: 7C49
• Specificity: Recognizes human, mouse and rat TP.
• Purity/Purification: Purified by immunoaffinity chromatography.
• Form/Format: Affinity Purified; Supplied as a liquid in PBS, pH 7.2, 0.1% sodium azide, before the addition of glycerol to 40%.
• Concentration: ~1mg/ml (varies by lot)
• Sequence Length: 471

• Applicable Applications for anti-Tymp antibody: Western Blot
• Application Notes: Suitable for use in Western Blot. Other applications not tested.; Dilution: Western Blot: 1-5ug/ml; Users must optimize antibody dilution depending upon the nature of samples and other technical conditions. TP is ~ 55kD. HUVEC cells or breast carcinoma or other tumor cells cab be used as positive controls.; Optimal dilutions to be determined by the researcher.
• Immunogen: Purified human recombinant TP protein
• Preparation and Storage: May be stored at 4 degree C for short-term only. For long-term storage, store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Related Product Information for anti-Tymp antibody

Platelet-derived endothelial growth factor (PD-ECGF), same as thymidine phosphorylase (TP; EC number 2.4.2.4) or gliostatin. Human TP is 482 aa (mature chain 11-482 aa; chromosome 22q13.32) dimeric protein. In the presence of inorganic orthophosphate, it catalyses the reversible phospholytic cleavage of thymidine and deoxyuridine to their corresponding bases and 2-deoxyribose-1- phosphate. It is both chemotactic and mitogenic for endothelial cells and a non-heparin binding angiogenic factor present in platelets. It is also involved in transformation of fluoropyrimidines, cytotoxic agents used in the treatment of a variety of malignancies, into active cytotoxic metabolites.

Product Categories/Family for anti-Tymp antibody

Abs to Enzymes

References

• 1. ishikawa F et al (1989) Nature 338, 557; Koukourakis MI et al (1997) 75, 477; Asai K et al (1992) JBC 267; 20311; Usuli K et al (1992) BBRC 184, 1311;

NCBI and Uniprot Product Information

• NCBI GI #: 19923857
• NCBI GeneID: 72962
• NCBI Accession #: NP_612175.1
• NCBI GenBank Nucleotide #: NM_138302.1
• UniProt Accession #: Q99N42
• Molecular Weight: 49,336 Da
• NCBI Official Full Name: thymidine phosphorylase
• NCBI Official Synonym Full Names: thymidine phosphorylase
• NCBI Official Symbol: Tymp
• NCBI Official Synonym Symbols: Ecgf1; PDECGF; Pdgfec; PD-ECGF; 2900072D10Rik
• NCBI Protein Information: thymidine phosphorylase; TP; tdRPase; gliostatin; platelet derived growth factor, endothelial cell; endothelial cell growth factor 1 (platelet-derived)
• UniProt Protein Name: Thymidine phosphorylase
• Protein Family: Thymidine phosphorylase
• UniProt Gene Name: Tymp
• UniProt Synonym Gene Names: Ecgf1
• UniProt Entry Name: TYPH_MOUSE