Mouse TBG Monoclonal Antibody | anti-TBG antibody

TBG antibody

Cat. Num. AAA532479

• Gene Names: SERPINA7; TBG
• Reactivity: To be determined by end-user
• Applications: User optimized
• Purity: > 90% pure; TBG antibody was purified by Protein A chromatography.
• Synonyms: TBG; Monoclonal Antibody; TBG antibody; Monoclonal TBG; Anti-TBG; T4 Binding Globulin; Anti TBG; Thyroxine Binding Globulin; anti-TBG antibody

• Host: Mouse
• Reactivity: To be determined by end-user
• Clonality: Monoclonal
• Isotype: IgG2a kappa
• Clone Number: 9311840
• Purity/Purification: > 90% pure; TBG antibody was purified by Protein A chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.4.
• Concentration: Typically ~ 5.0 mg/ml (varies by lot)
• Sequence Length: 415

• Applicable Applications for anti-TBG antibody: User optimized
• Biological Significance: Thyroxine-binding globulin (TBG) binds thyroid hormone in circulation. It is one of three proteins (along with transthyretin and albumin) responsible for carrying the thyroid hormones thyroxine (T4) and 3,5,3?-triiodothyronine (T3) in the bloodstream. Of these three proteins, TBG has the highest affinity for T4 and T3, but is present in the lowest concentration. Despite its low concentration, TBG carries the majority of T4 in the blood.
• Preparation and Storage: Store at 4 degree C for short term storage. Aliquot and store at -20 degree C for long term storage. Avoid repeated freeze/thaw cycles.

Related Product Information for anti-TBG antibody

Mouse monoclonal TBG antibody

Product Categories/Family for anti-TBG antibody

Hormones & Steroids

NCBI and Uniprot Product Information

• NCBI GI #: 205277441
• NCBI GeneID: 6906
• NCBI Accession #: NP_000345.2
• NCBI GenBank Nucleotide #: NM_000354.5
• UniProt Accession #: P05543; D3DUX1
• Molecular Weight: 46,325 Da
• NCBI Official Full Name: thyroxine-binding globulin
• NCBI Official Synonym Full Names: serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7
• NCBI Official Symbol: SERPINA7
• NCBI Official Synonym Symbols: TBG
• NCBI Protein Information: thyroxine-binding globulin
• UniProt Protein Name: Thyroxine-binding globulin
• UniProt Gene Name: SERPINA7
• UniProt Synonym Gene Names: TBG
• UniProt Entry Name: THBG_HUMAN

NCBI Description

There are three proteins including thyroxine-binding globulin (TBG), transthyretin and albumin responsible for carrying the thyroid hormones thyroxine (T4) and 3,5,3'-triiodothyronine (T3) in the bloodstream. This gene encodes the major thyroid hormone transport protein, TBG, in serum. It belongs to the serpin family in genomics, but the protein has no inhibitory function like many other members of the serpin family. Mutations in this gene result in TGB deficiency, which has been classified as partial deficiency, complete deficiency, and excess, based on the level of serum TBG. Alternatively spliced transcript variants encoding different isoforms have been found, but the full-length nature of these variants has not been determined.[provided by RefSeq, Jun 2012]

Uniprot Description

SERPINA7: Major thyroid hormone transport protein in serum. Defects in SERPINA7 are a cause of thyroxine-binding globulin deficiency (TBG deficiency). Mutations in the SERPINA7 gene can result as a whole spectrum of deficiencies, characterized by either reduced or increased TBG levels in the serum. Patients show, respectively, reduced or elevated protein- bound iodine but are euthyroid. Belongs to the serpin family.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: Xq22.2

Cellular Component: extracellular space; extracellular region

Molecular Function: serine-type endopeptidase inhibitor activity; hormone binding

Biological Process: response to drug; response to peptide hormone stimulus; post-embryonic development; response to vitamin A; aging; response to corticosterone stimulus