Mouse anti-Human TACSTD2/TROP-2 Monoclonal Antibody | anti-TACSTD2/TROP-2 antibody

Anti-human TACSTD2/TROP-2 Monoclonal Antibody

Cat. Num. AAA415353

• Gene Names: TACSTD2; EGP1; GP50; M1S1; EGP-1; TROP2; GA7331; GA733-1
• Reactivity: Human
• Applications: Immunofluorescence, Immunocytochemistry
• Purity: Affinity purified
• Synonyms: TACSTD2/TROP-2; Monoclonal Antibody; Anti-human TACSTD2/TROP-2 Monoclonal Antibody; Anti-human TACSTD2/TROP-2 Monoclonal; anti-TACSTD2/TROP-2 antibody

• Host: Mouse
• Reactivity: Human
• Clonality: Monoclonal
• Isotype: IgG1 (Igh-4a allotype)
• Specificity: The antibody defines TROP-2 that is expressed on trophoblasts and choriocarcinoma cells but not on blood cells or other tumor cells.
• Purity/Purification: Affinity purified
• Form/Format: Liquid
• Concentration: 100ug/100ul (varies by lot)
• Sequence Length: 2080

• Applicable Applications for anti-TACSTD2/TROP-2 antibody: Immunofluorescence (IF), Immunocytochemistry (ICC)
• Application Notes: Immunostaining, immunofluorescence: optimal dilutions to be determined by researchers.
• Immunogen: Human choriocarcinoma cell line BeWo
• Antibody Type: Primary Antibody
• Storage Buffer: PBS, pH 7.4 with 0.02% sodium azide.
• Preparation and Storage: This product is stable for several weeks at 4 degree C as an undiluted liquid. Dilute only prior to immediate use. For extended storage, aliquot contents and freeze at -20 degree C or below. Avoid cycles of freezing and thawing. Expiration date is one (1) year from date of receipt.

Immunohistochemistry (IHC)

Related Product Information for anti-TACSTD2/TROP-2 antibody

Tumor-associated calcium signal transducer 2, a carcinoma-associated antigen defined by the monoclonal antibody GA733. This antigen is a member of a family including at least two type I membrane proteins. It transduces an intracellular calcium signal and acts as a cell surface receptor. Mutations of this gene result in gelatinous drop-like corneal dystrophy, an autosomal recessive disorder characterized by severe corneal amyloidosis leading to blindness. Clone #: 162-46.2

References

Lipinski M, et al. Human trophoblast cell-surface antigens defined by monoclonal antibodies. Proc. Natl. Acad. Sci. USA 78: 5147-5150, 1981.

NCBI and Uniprot Product Information

• NCBI GI #: 166795235
• NCBI GeneID: 4070
• NCBI Accession #: NP_002344.2
• NCBI GenBank Nucleotide #: NM_002353.2
• UniProt Accession #: P09758; Q15658; Q6FG48; Q7Z7Q4; Q96QD2
• Molecular Weight: 35,709 Da
• NCBI Official Full Name: Homo sapiens tumor-associated calcium signal transducer 2 (TACSTD2), mRNA
• NCBI Official Synonym Full Names: tumor-associated calcium signal transducer 2
• NCBI Official Symbol: TACSTD2
• NCBI Official Synonym Symbols: EGP1; GP50; M1S1; EGP-1; TROP2; GA7331; GA733-1
• NCBI Protein Information: tumor-associated calcium signal transducer 2; epithelial glycoprotein-1; cell surface glycoprotein TROP2; cell surface glycoprotein Trop-2; pancreatic carcinoma marker protein GA7331; pancreatic carcinoma marker protein GA733-1; gastrointestinal tumor-associated antigen GA7331; membrane component chromosome 1 surface marker 1; membrane component, chromosome 1, surface marker 1; 40kD glycoprotein, identified by monoclonal antibody GA733
• UniProt Protein Name: Tumor-associated calcium signal transducer 2
• UniProt Gene Name: TACSTD2
• UniProt Synonym Gene Names: GA733-1; M1S1; TROP2
• UniProt Entry Name: TACD2_HUMAN

NCBI Description

This intronless gene encodes a carcinoma-associated antigen. This antigen is a cell surface receptor that transduces calcium signals. Mutations of this gene have been associated with gelatinous drop-like corneal dystrophy.[provided by RefSeq, Dec 2009]

Uniprot Description

Function: May function as a growth factor receptor.

Subcellular location: Membrane; Single-pass type I membrane protein.

Tissue specificity: Placenta, pancreatic carcinoma cell lines.

Post-translational modification: The N-terminus is blocked.

Involvement in disease: Corneal dystrophy, gelatinous drop-like (GDLD) [MIM:204870]: A form of lattice corneal dystrophy, a class of inherited stromal amyloidoses characterized by pathognomonic branching lattice figures in the cornea. GDLD is an autosomal recessive disorder characterized by severe corneal amyloidosis leading to blindness. Clinical manifestations, which appear in the first decade of life, include blurred vision, photophobia, and foreign-body sensation. By the third decade, raised, yellowish-gray, gelatinous masses severely impair visual acuity.Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.8

Sequence similarities: Belongs to the EPCAM family.Contains 1 thyroglobulin type-1 domain.