Mouse anti-Human SORL1 Monoclonal Antibody | anti-SORL1 antibody

SORL1 Mouse mAb

Cat. Num. AAA8538385

• Reactivity: Human
• Applications: Western Blot, Immunohistochemistry, Immunocytochemistry, Flow Cytometry, Functional Assay, ELISA
• Purity: Ascitic Fluid
• Synonyms: SORL1; Monoclonal Antibody; SORL1 Mouse mAb; anti-SORL1 antibody

• Host: Mouse
• Reactivity: Human
• Clonality: Monoclonal
• Isotype: IgG1
• Clone Number: 7D7B11
• Purity/Purification: Ascitic Fluid
• Form/Format: Ascitic fluid containing 0.03% Sodium Azide.
• Sequence Length: 2214

• Applicable Applications for anti-SORL1 antibody: Western Blot (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Flow Cytometry (FC/FACS), ELISA (EIA)
• Application Notes: WB: 1:500-1:2000; ELISA: 1:10000
• Immunogen: Purified recombinant fragment of SORL1 (aa2159-2214) expressed in E. Coli.
• Cellular Localization: Endosome, Golgi Apparatus, LDL, Membrane, Secreted
• Preparation and Storage: Store at 4 degree C short term. Store at -20 degree C long term. Avoid freeze/thaw cycle.

Related Product Information for anti-SORL1 antibody

SORL1 (sortilin-related receptor, L A repeats containing) also known as sorting protein-related receptor containing LDLR class A (SorLA), is a Type I membrane protein that may be involved in cell-cell interaction. SorLA, a single transmembrane receptor, binds LDL and transports it into cells by endocytosis. SorLA is synthesized as a proreceptor which is processed to the mature form by a furin-like propeptidase. It can also bind to RAP (receptor-associated protein). SorLA is a multifunctional endocytis receptor important in lipoprotein and protease uptake. The N-terminal propeptide, which is removed, can be cleaved by furin or homologous proteases. Endogenous SorLA binds the neuropeptide head activator (HA) and is important for HA signaling and function. The gene encoding for the protein maps to chromosome 8p23.1. SorLA is expressed mainly in brain (cerebral cortex, cerebellum and the occipital pole), but can also be found in liver, spinal cord, kidney, testis and pancreas.

NCBI and Uniprot Product Information

• NCBI GI #: 4507157
• NCBI GeneID: 6653
• NCBI Accession #: NP_003096.1
• NCBI GenBank Nucleotide #: NP_003096.1
• UniProt Accession #: Q92673
• NCBI Official Full Name: sortilin-related receptor preproprotein
• UniProt Protein Name: Sortilin-related receptor
• Protein Family: Sortilin-related receptor
• UniProt Gene Name: SORL1
• UniProt Synonym Gene Names: C11orf32; LDLR relative with 11 ligand-binding repeats; LR11; SorLA
• UniProt Entry Name: SORL_HUMAN

Uniprot Description

SORL1: Likely to be a multifunctional endocytic receptor, that may be implicated in the uptake of lipoproteins and of proteases. Binds LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. Binds the receptor- associated protein (RAP). Could play a role in cell-cell interaction. Belongs to the VPS10-related sortilin family. SORL1 subfamily.

Protein type: Cell surface; Receptor, misc.; Membrane protein, integral

Chromosomal Location of Human Ortholog: 11q23.2-q24.2

Cellular Component: Golgi apparatus; extracellular space; Golgi cisterna; integral to plasma membrane; endoplasmic reticulum; early endosome; trans-Golgi network; multivesicular body; recycling endosome; cell soma; membrane; nuclear envelope lumen; endosome

Molecular Function: ADP-ribosylation factor binding; protein binding; transmembrane receptor activity; beta-amyloid binding; low-density lipoprotein binding

Biological Process: cholesterol metabolic process; negative regulation of MAP kinase activity; receptor-mediated endocytosis; protein targeting to lysosome; cell migration; protein maturation; lipid transport; signal transduction; negative regulation of neurogenesis; negative regulation of protein oligomerization; cell proliferation; regulation of smooth muscle cell migration; positive regulation of protein catabolic process; post-Golgi vesicle-mediated transport; protein targeting to Golgi; negative regulation of protein binding; protein retention in Golgi; protein targeting

Disease: Alzheimer Disease