Mouse anti-Human SLC18A1 Monoclonal Antibody | anti-SLC18A1 antibody

SLC18A1 (Chromaffin Granule Amine Transporter, Solute Carrier Family 18 Member 1, Vesicular Amine Transporter 1, VAT1, VAT1, VMAT1)

Cat. Num. AAA645706

• Gene Names: SLC18A1; CGAT; VAT1; VMAT1
• Reactivity: Human
• Applications: ELISA, Western Blot
• Purity: Affinity Purified; Purified by Protein A affinity chromatography.
• Synonyms: SLC18A1; Monoclonal Antibody; SLC18A1 (Chromaffin Granule Amine Transporter; Solute Carrier Family 18 Member 1; Vesicular Amine Transporter 1; VAT1; VMAT1); Anti -SLC18A1 (Chromaffin Granule Amine Transporter; anti-SLC18A1 antibody

• Host: Mouse
• Reactivity: Human
• Clonality: Monoclonal
• Isotype: IgG2b,k
• Clone Number: 3A2-E10
• Specificity: Recognizes human SLC18A1.
• Purity/Purification: Affinity Purified; Purified by Protein A affinity chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2.
• Sequence: MLRPILDAPQRLLKEGRASRQLVLVVVFVALLLDNMLFTVVVPIVPTFLYDMEFKEVNSSLHLGHAGSSPHALASPAFSTIFSFFNNNTVAVEESVPSGIAWMNDTASTIPPPATEAISAHKNNCLQGTGFLEEETTRVGVLFASKAVMQLLVNPFVGPLTNRIGYHIPMFAGFVIMFLSTVMFAFSGTYTLLFVARTLQGIGSSFSSVAGLGMLASVYTDDHERGRAMGTALGGLALGLLVGAPFGSVMYEFVGKSAPFLILAFLALLDGALQLCILQPSKVSPESAKGTPLFMLLKDPYILVAAGLAFLPASVSYLIGTNLFGVLANKMGRWLCSLIGMLVVGTSLLCVPLAHNIFGLIGPNAGLGLAIGMVDSSMMPIMGHLVDLRHTSVYGSVYAIADVAFCMGFAIGPSTGGAIVKAIGFPWLMVITGVINIVYAPLCYYLRSPPAKEEKLAILSQDCPMETRMYATQKPTKEFPLGEDSDEEPDHEE

• Applicable Applications for anti-SLC18A1 antibody: ELISA (EL/EIA), Western Blot (WB)
• Application Notes: Suitable for use in ELISA and Western Blot.
• Immunogen: Full length recombinant corresponding to aa1-494 from human SLC18A1 (AAH06317) with GST tag. MW of the GST tag alone is 26kD.
• Preparation and Storage: May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(Western Blot detection against Immunogen (80.34kD).)

Western Blot (WB)

(SLC18A1 monoclonal antibody, Western Blot analysis of SLC18A1 expression in A-549.)

Related Product Information for anti-SLC18A1 antibody

The vesicular monoamine transporter acts to accumulate cytosolic monoamines into vesicles, using the proton gradient maintained across the vesicular membrane. Its proper function is essential to the correct activity of the monoaminergic systems that have been implicated in several human neuropsychiatric disorders. The transporter is a site of action of important drugs, including reserpine and tetrabenazine (Peter et al., 1993 [PubMed 7905859]). See also SLC18A2 (MIM 193001).[supplied by OMIM]

Product Categories/Family for anti-SLC18A1 antibody

Antibodies; Abs to Ion Channel

NCBI and Uniprot Product Information

• NCBI GI #: 14424746
• NCBI GeneID: 6570
• UniProt Accession #: P54219; Q9BRE4; E9PDJ5
• Molecular Weight: 56,257 Da
• NCBI Official Full Name: SLC18A1 protein
• NCBI Official Synonym Full Names: solute carrier family 18 (vesicular monoamine transporter), member 1
• NCBI Official Symbol: SLC18A1
• NCBI Official Synonym Symbols: CGAT; VAT1; VMAT1
• NCBI Protein Information: chromaffin granule amine transporter; vesicular amine transporter 1; solute carrier family 18 member 1; solute carrier family 18 (vesicular monoamine), member 1
• UniProt Protein Name: Chromaffin granule amine transporter
• Protein Family: Chromaffin granule amine transporter
• UniProt Gene Name: SLC18A1
• UniProt Synonym Gene Names: VAT1; VMAT1; VAT1
• UniProt Entry Name: VMAT1_HUMAN

NCBI Description

The vesicular monoamine transporter acts to accumulate cytosolic monoamines into vesicles, using the proton gradient maintained across the vesicular membrane. Its proper function is essential to the correct activity of the monoaminergic systems that have been implicated in several human neuropsychiatric disorders. The transporter is a site of action of important drugs, including reserpine and tetrabenazine (Peter et al., 1993 [PubMed 7905859]). See also SLC18A2 (MIM 193001).[supplied by OMIM, Mar 2008]

Uniprot Description

Function: Involved in the transport of biogenic monoamines, such as serotonin, from the cytoplasm into the secretory vesicles of neuroendocrine and endocrine cells. Ref.4

Subcellular location: Isoform 1: Cytoplasmic vesicle membrane; Multi-pass membrane protein Ref.4. Isoform 2: Endoplasmic reticulum membrane; Multi-pass membrane protein Ref.4.

Sequence similarities: Belongs to the major facilitator superfamily. Vesicular transporter family.