Rabbit anti-Mouse SIGNR1 Monoclonal Antibody | anti-CD209B antibody
Recombinant Anti-SIGNR1 Antibody, Rabbit Monoclonal
Gene Names
Cd209b; OtB7; SIGNR1; mSIGNR1; DC-SIGNR1; 1810030I22Rik
Reactivity
Mouse
Applications
ELISA
Purity
Protein A
Synonyms
SIGNR1; Monoclonal Antibody; Recombinant Anti-SIGNR1 Antibody; Rabbit Monoclonal; SIGNR1/CD209b Antibody; Rabbit MAb; CD209b antigen; Anti-1810030I22Rik Antibody; Anti-DC-SIGNR1 Antibody; Anti-mSIGNR1 Antibody; Anti-OtB7 Antibody; Anti-SIGNR1 Antibody; anti-CD209B antibody
Host
Rabbit
Reactivity
Mouse
Clonality
Monoclonal
Isotype
Rabbit IgG
Clone Number
123
Specificity
Mouse SIGNR1/CD209b
Purity/Purification
Protein A
Form/Format
Liquid; 0.2um filtered solution in PBS
Applicable Applications for anti-CD209B antibody
ELISA (EIA) (Cap)
Application Notes
ELISA (Cap): This antibody will detect Mouse SIGNR1/CD209b in ELISA pair set.
In a sandwich ELISA, it can be used as capture antibody when paired with.
In a sandwich ELISA, it can be used as capture antibody when paired with.
Antibody Type
Recombinant Antibody
Immunogen
Recombinant Mouse SIGNR1/CD209b Protein
Conjugation
Unconjugated
Preparation
This antibody was obtained from a rabbit immunized with purified, recombinant Mouse SIGNR1/CD209b (rM SIGNR1/CD209b).
Preparation and Storage
This antibody can be stored at 2-8 degree C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 degree C to -80 degree C. Preservative-Free. Avoid repeated freeze-thaw cycles.
Related Product Information for anti-CD209B antibody
The cluster of differentiation (CD) system is commonly used as cell markers in Immunophenotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules associating with the immune function of the cell. There are more than 320 CD unique clusters and subclusters have been identified. Some of the CD molecules serve as receptors or ligands important to the cell through initiating a signal cascade which then alter the behavior of the cell. Some CD proteins do not take part in cell signal process but have other functions such as cell adhesion. CD209b, also known as SIGNR1, is a C-type lectin receptor. CD209b is present on most regions of mouse brain and found on microglia and dendritic cells but not on neurons or astrocytes. CD209b is implicated in the recently described SIGNR1 complement activation pathway, which operates against capsular polysaccharides in splenic marginal macrophages. CD209b in rat is homologue to SIGNR1 in mouse, both of which are found to mediate the uptake of dextran or CPS14 within the splenic marginal zone.
References
Zola H, et al. (2007) CD molecules 2006-human cell differentiation molecules. J Immunol Methods. 318 (1-2): 1-5.Ho IC, et al. (2009) GATA3 and the T-cell lineage: essential functions before and after T-helper-2-cell differentiation. Nat Rev Immunol. 9 (2): 125-35.Matesanz-Isabel J, et al. (2011) New B-cell CD molecules. Immunology Letters.134 (2): 104-12.Park JY, et al. (2009) The C-type lectin CD209b is expressed on microglia and it mediates the uptake of capsular polysaccharides of Streptococcus pneumonia. Neuroscience Letters. 450 (3): 246-51.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
16,471 Da
NCBI Official Full Name
CD209 antigen-like protein B isoform a
NCBI Official Synonym Full Names
CD209b antigen
NCBI Official Symbol
Cd209b
NCBI Official Synonym Symbols
OtB7; SIGNR1; mSIGNR1; DC-SIGNR1; 1810030I22Rik
NCBI Protein Information
CD209 antigen-like protein B
UniProt Protein Name
CD209 antigen-like protein B
Protein Family
UniProt Gene Name
Cd209b
UniProt Synonym Gene Names
DC-SIGNR1
UniProt Entry Name
C209B_MOUSE
Uniprot Description
CD209B: Probable pathogen-recognition receptor. May mediate the endocytosis of pathogens which are subsequently degraded in lysosomal compartments. May recognize in a calcium-dependent manner high mannose N-linked oligosaccharides in a variety of pathogen antigens. Is a receptor for ICAM3, probably by binding to mannose-like carbohydrates. 4 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral
Cellular Component: membrane; integral to membrane; external side of plasma membrane
Molecular Function: mannose binding; metal ion binding; zymosan binding; carbohydrate binding; polysaccharide binding
Biological Process: positive regulation of tumor necrosis factor biosynthetic process; detection of bacterium; positive regulation of phagocytosis; endocytosis; phagocytosis, recognition; detection of yeast
