Western Blot (WB)
()
Mouse SHP2 Monoclonal Antibody | anti-SHP2 antibody
SHP2 antibody
Applications
Western Blot, Immunoprecipitation
Purity
SHP2 antibody was purified by ammonium sulfate precipitation
Synonyms
SHP2; Monoclonal Antibody; SHP2 antibody; Monoclonal SHP2; Anti-SHP2; PTPN11; protein tyrosine phosphatase; non-receptor type 11; BOS_16688; BPTP3; CFC; cSH-PTP2; encodes catalytic domain; non-receptor type protein tyrosine phosphatase SHP2; NS1; null; phosphotyrosyl-protein phosphatase; protein-tyrosine phosphatase 1D; protein-tyrosine phosphatase 2C; non-receptor type 11 (Noonan syndrome 1); protein tyrosine phosphatase SH-PTP2; protein-tyrosine phosphatase SYP; PTP1D; PTP-1D; ptp-2; PTP2C; PTP-2C; SAP-2; SH2 domain-containing protein tyrosine phosphatase-2; Shp2; SHP-2; SH-PTP2; SH-PTP2 protein tyrosine phosphatase non-receptor type 11; SH-PTP2 protein tyrosine phosphatase; SH-PTP3; SYP; tyrosine-protein phosphatase non-receptor type 11; anti-SHP2 antibody
Host
Mouse
Clonality
Monoclonal
Isotype
IgG1
Clone Number
5F2
Purity/Purification
SHP2 antibody was purified by ammonium sulfate precipitation
Form/Format
Protein G purified liquid in HEPES with 150mM NaCl, 0.01% BSA, 50% glycerol and 0.03% NaN3.
Concentration
2.0mg/ml (varies by lot)
Sequence Length
244
Applicable Applications for anti-SHP2 antibody
Western Blot (WB), Immunoprecipitation (IP)
Application Notes
WB: 1:2000
IP: 1 ul
IP: 1 ul
Biological Significance
SHP2 is a tyrosine phosphatase containing two tandem SH2 (src homology 2) domains. Protein tyrosine phosphatases (PTPs) are a group of enzymes that remove phosphate groups from phosphorylated tyrosine residues on proteins. Together with tyrosine kinases, PTPs regulate the phosphorylation state of many important signaling molecules. SHP1 and SHP2 represent a subfamily of non-transmembrane PTPs that contain two SH2 domains followed by a PTP domain. Tyrosine phosphorylation of SHP2 is required for normal ERK activation in response to some growth factors. In the inactive state, the N-terminal SH2 domain binds the PTP domain and blocks access of potential substrates to the active site. This auto-inhibition is relieved by the binding of phosphopeptides to SH2 domain, resulting in activation of phostphatase activity.
Cross-Reactivity
Human, Mouse, Rat
Immunogen
SHP2 antibody was raised in Mouse using a recombinant human GST-SHP2 protein purified from E Coli as the immunogen
Preparation and Storage
4 degree C for short term, -20 degree C for long term.
Western Blot (WB)
()
Western Blot (WB)
()
Related Product Information for anti-SHP2 antibody
Mouse monoclonal SHP2 antibody
Product Categories/Family for anti-SHP2 antibody
NCBI and Uniprot Product Information
NCBI GI #
Molecular Weight
28,006 Da
NCBI Official Full Name
shatterproof 2
UniProt Protein Name
BnaA05g02990D protein
UniProt Gene Name
SHP2
UniProt Entry Name
B1PHV6_BRANA
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Product Notes
The SHP2 shp2 (Catalog #AAA833852) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. AAA Biotech's SHP2 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunoprecipitation (IP). WB: 1:2000 IP: 1 ul. Researchers should empirically determine the suitability of the SHP2 shp2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "SHP2, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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