Rabbit anti-Human SerpinI2  Monoclonal Antibody | anti-SerpinI2  antibody

Rabbit anti Human SerpinI2  Monoclonal Antibody

Cat. Num. AAA2544141

• Gene Names: SERPINI2; MEPI; PI14; PANCPIN; TSA2004
• Reactivity: Human
• Applications: ELISA
• Synonyms: SerpinI2 ; Monoclonal Antibody; Rabbit anti Human SerpinI2 Monoclonal Antibody; anti-SerpinI2 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Monoclonal
• Isotype: IgG
• Sequence Length: 415

• Applicable Applications for anti-SerpinI2 antibody: ELISA (EIA)
• Application Notes: ELISA: 0.1-0.2 mug/mL. This antibody can be used at 0.1-0.2 mug/mL with the appropriate secondary reagents to detect Human SerpinI2. The detection limit for Human SerpinI2 is approximately 0.0049 ng/well.
• Immunogen: Recombinant Human SerpinI2 protein
• Buffer: 0.2 mum filtered solution in PBS with 5% trehalose
• Preparation and Storage: This antibody can be stored at 2 degree C- 8 degree C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 degree C to -80 degree C. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.

Related Product Information for anti-SerpinI2  antibody

Serpins are the largest and most diverse family of serine protease inhibitors which are involved in a number of fundamental biological processes such as blood coagulation, complement activation, fibrinolysis, angiogenesis, inflammation and tumor suppression and are expressed in a cell-specific manner. Serpins are a group of proteins with similar structures that were first identified as a set of proteins able to inhibit proteases. The acronym serpin was originally coined because many serpins inhibit chymotrypsin-like serine proteases (serine protease inhibitors). Over 1000 serpins have been identified. Serpin-I2, also known as myoepithelium-derived serine protease inhibitor, Pancreas-specific protein TSA2004, Peptidase inhibitor 14, PI14, SERPINI2 and MEPI, is a secreted protein which belongs to the serpin family. It is expressed in pancreas and adipose tissues. SERPINI2 deficiency directly results in the acinar cell apoptosis and malabsorption.

NCBI and Uniprot Product Information

• NCBI GI #: 59814581
• NCBI GeneID: 5276
• NCBI GenBank Nucleotide #: NM_001012303.2
• Molecular Weight: 46,145 Da
• NCBI Official Full Name: serpin I2 isoform 1
• NCBI Official Synonym Full Names: serpin family I member 2
• NCBI Official Symbol: SERPINI2
• NCBI Official Synonym Symbols: MEPI; PI14; PANCPIN; TSA2004
• NCBI Protein Information: serpin I2
• UniProt Protein Name: Serpin I2
• UniProt Gene Name: SERPINI2
• UniProt Synonym Gene Names: MEPI; PI14; PI-14
• UniProt Entry Name: SPI2_HUMAN

NCBI Description

The gene encodes a member of a family of proteins that acts as inhibitors of serine proteases. These proteins function in the regulation of a variety of physiological processes, including coagulation, fibrinolysis, development, malignancy, and inflammation. Expression of the encoded protein may be downregulated during pancreatic carcinogenesis. Alternative splicing results in multiple transcript variants for this gene. [provided by RefSeq, Jan 2013]

Uniprot Description

SERPINI2: is a member of the serine protease inhibitor (serpin) superfamily made up of proteins which play central roles in the regulation of a wide variety of physiological processes, including coagulation, fibrinolysis, development, malignancy and inflammation. The gene product may have a role in a growth-control, possibly growth-suppressing pathway and, when impaired, may be involved in pancreatic carcinogenesis. The protein is a member of the plasminogen activator inhibitor-1 family, a subset of the serpin superfamily whose members act as tissue-specific tPA inhibitors. Two alternatively spliced transcript variants encoding distinct protein isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 3q26.1

Cellular Component: extracellular space

Molecular Function: protein binding

Biological Process: cell motility