Flow Cytometry (FC/FACS)
(Flow cytometric analysis of Human SERPINI2 expression on U2OS cells. Cells were stained with purified anti-Human SERPINI2, then a FITC-conjugated second step antibody. The fluorescence histograms were derived from gated events with the forward and side light-scatter characteristics of intact cells.)
Rabbit anti-Human SerpinI2 Monoclonal Antibody | anti-SerpinI2 antibody
Recombinant Anti-SerpinI2 Antibody, Rabbit Monoclonal
Gene Names
SERPINI2; MEPI; PI14; PANCPIN; TSA2004
Reactivity
Human
Applications
ELISA, Flow Cytometry, Functional Assay
Purity
Protein A
Synonyms
SerpinI2; Monoclonal Antibody; Recombinant Anti-SerpinI2 Antibody; Rabbit Monoclonal; SerpinI2 Antibody; Rabbit MAb; serpin peptidase inhibitor; clade I (pancpin); member 2; Anti-MEPI Antibody; Anti-PANCPIN Antibody; Anti-PI14 Antibody; Anti-Serpin I2 Antibody; Anti-TSA2004 Antibody; anti-SerpinI2 antibody
Host
Rabbit
Reactivity
Human
Clonality
Monoclonal
Isotype
Rabbit IgG
Clone Number
018
Specificity
Human SerpinI2
Purity/Purification
Protein A
Form/Format
Liquid; 0.2um filtered solution in PBS
Applicable Applications for anti-SerpinI2 antibody
ELISA (EIA), Flow Cytometry (FC/FACS/FCM)
Application Notes
ELISA: 1:5000-1:10,000
FC/FACS/FCM: 1:25-1:100
FC/FACS/FCM: 1:25-1:100
Antibody Type
Recombinant Antibody
Immunogen
Recombinant Human SerpinI2 protein
Conjugation
Unconjugated
Preparation
This antibody was obtained from a rabbit immunized with purified, recombinant Human SerpinI2 (rh SerpinI2).
Preparation and Storage
This antibody can be stored at 2-8 degree C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 degree C to -80 degree C. Preservative-Free. Avoid repeated freeze-thaw cycles.
Flow Cytometry (FC/FACS)
(Flow cytometric analysis of Human SERPINI2 expression on U2OS cells. Cells were stained with purified anti-Human SERPINI2, then a FITC-conjugated second step antibody. The fluorescence histograms were derived from gated events with the forward and side light-scatter characteristics of intact cells.)
Flow Cytometry (FC/FACS)
(Flow cytometric analysis of Human SERPINI2 expression on U2OS cells. Cells were stained with purified anti-Human SERPINI2, then a FITC-conjugated second step antibody. The fluorescence histograms were derived from gated events with the forward and side light-scatter characteristics of intact cells.)
Related Product Information for anti-SerpinI2 antibody
Serpins are the largest and most diverse family of serine protease inhibitors which are involved in some fundamental biological processes such as blood coagulation, complement activation, fibrinolysis, angiogenesis, inflammation and tumor suppression and are expressed in a cell-specific manner. Serpins are a group of proteins with similar structures that were first identified as a set of proteins able to inhibit proteases. The acronym serpin was originally coined because many serpins inhibit chymotrypsin-like serine proteases (serine protease inhibitors). Over 1 serpins have been identified.
Serpin-I2, also known as myoepithelium-derived serine protease inhibitor, Pancreas-specific protein TSA24, Peptidase inhibitor 14, PI14, SERPINI2 and MEPI, is a secreted protein that belongs to the serpin family. It is expressed in pancreas and adipose tissues. SERPINI2 deficiency directly results in the acinar cell apoptosis and malabsorption.
Serpin-I2, also known as myoepithelium-derived serine protease inhibitor, Pancreas-specific protein TSA24, Peptidase inhibitor 14, PI14, SERPINI2 and MEPI, is a secreted protein that belongs to the serpin family. It is expressed in pancreas and adipose tissues. SERPINI2 deficiency directly results in the acinar cell apoptosis and malabsorption.
References
Riewald M. et al., 1995, J. Biol. Chem. 270: 26754-7. Forsyth, S. et al., 2003, Genomics 81: 336-45. Horvath, AJ. et al., 2004, J. Mol. Evol. 59: 488-97. Loftus, S.K. et al., 2005, PLoS Genet. 1 (3):e38. Steenbakkers PJ. et al., 2008, Mycol. Res. 112 (Pt 8): 999-1006. Przygodzka, P. et al., 2010, BMC Cell Biol. 11: 30.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
46,145 Da
NCBI Official Full Name
serpin I2 isoform 2
NCBI Official Synonym Full Names
serpin family I member 2
NCBI Official Symbol
SERPINI2
NCBI Official Synonym Symbols
MEPI; PI14; PANCPIN; TSA2004
NCBI Protein Information
serpin I2
Protein Family
NCBI Description
The gene encodes a member of a family of proteins that acts as inhibitors of serine proteases. These proteins function in the regulation of a variety of physiological processes, including coagulation, fibrinolysis, development, malignancy, and inflammation. Expression of the encoded protein may be downregulated during pancreatic carcinogenesis. Alternative splicing results in multiple transcript variants for this gene. [provided by RefSeq, Jan 2013]
Research Articles on SerpinI2
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Product Notes
The SerpinI2 (Catalog #AAA8104563) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Recombinant Anti-SerpinI2 Antibody, Rabbit Monoclonal reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's SerpinI2 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Flow Cytometry (FC/FACS/FCM). ELISA: 1:5000-1:10,000 FC/FACS/FCM: 1:25-1:100. Researchers should empirically determine the suitability of the SerpinI2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "SerpinI2, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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