Rabbit anti-Mouse SerpinB8  Monoclonal Antibody | anti-SerpinB8  antibody

Rabbit anti Mouse SerpinB8  Monoclonal Antibody

Cat. Num. AAA2544518

• Gene Names: SERPINB8; PI8; CAP2; PSS5
• Reactivity: Mouse
• Applications: ELISA
• Synonyms: SerpinB8 ; Monoclonal Antibody; Rabbit anti Mouse SerpinB8 Monoclonal Antibody; anti-SerpinB8 antibody

• Host: Rabbit
• Reactivity: Mouse
• Clonality: Monoclonal
• Isotype: IgG
• Sequence Length: 192

• Applicable Applications for anti-SerpinB8 antibody: ELISA (EIA)
• Application Notes: ELISA: 0.1-0.2 mug/mL. This antibody can be used at 0.1-0.2 mug/mL with the appropriate secondary reagents to detect Mouse SerpinB8. The detection limit for Mouse SerpinB8 is approximately 0.00975 ng/well.
• Immunogen: Recombinant Mouse SerpinB8 protein
• Buffer: This antibody was obtained from a rabbit immunized with purified, recombinant Mouse SerpinB8 (rM SerpinB8; NP_035589.1; Met 1-Pro 374).
• Preparation and Storage: This antibody can be stored at 2 degree C- 8 degree C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 degree C to -70 degree C. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.

Related Product Information for anti-SerpinB8  antibody

Serpins are the largest and most diverse family of serine protease inhibitors which are involved in a number of fundamental biological processes such as blood coagulation, complement activation, fibrinolysis, angiogenesis, inflammation and tumor suppression and are expressed in a cell-specific manner. Mouse SerpinB8, also known as Cytoplasmic antiproteinase 2, Peptidase inhibitor 8, SerpinB8, PI-8, SERPINB8 and CAP2, is a member of the Serpin superfamily. SERPINB8 was broadly expressed. In normal neuroendocrine tissues, strongest SerpinB8 expression was detected in islets of Langerhans of the pancreas. Moderate SerpinB8 expression was observed in neuroendocrine cells of the thyroid, adrenal cortex, colon, and pituitary gland. In the pancreas, SerpinB8 is specifically expressed by insulin-producing beta cells, and can be used as an additional immunohistochemical marker. Mouse SerpinB8 distribution alters during kidney regeneration, possibly to control a prohormone convertase involved in inflammation or tissue repair.

NCBI and Uniprot Product Information

• NCBI GI #: 451770404
• NCBI GeneID: 5271
• NCBI GenBank Nucleotide #: NM_001276490.1
• Molecular Weight: 22,134 Da
• NCBI Official Full Name: serpin B8 isoform c
• NCBI Official Synonym Full Names: serpin family B member 8
• NCBI Official Symbol: SERPINB8
• NCBI Official Synonym Symbols: PI8; CAP2; PSS5
• NCBI Protein Information: serpin B8
• UniProt Protein Name: Serpin B8
• UniProt Gene Name: SERPINB8
• UniProt Synonym Gene Names: PI8; CAP-2; CAP2; PI-8
• UniProt Entry Name: SPB8_HUMAN

NCBI Description

The superfamily of high molecular weight serine proteinase inhibitors (serpins) regulate a diverse set of intracellular and extracellular processes such as complement activation, fibrinolysis, coagulation, cellular differentiation, tumor suppression, apoptosis, and cell migration. Serpins are characterized by well-conserved a tertiary structure that consists of 3 beta sheets and 8 or 9 alpha helices (Huber and Carrell, 1989 [PubMed 2690952]). A critical portion of the molecule, the reactive center loop connects beta sheets A and C. Protease inhibitor-8 (PI8; SERPINB8) is a member of the ov-serpin subfamily, which, relative to the archetypal serpin PI1 (MIM 107400), is characterized by a high degree of homology to chicken ovalbumin, lack of N- and C-terminal extensions, absence of a signal peptide, and a serine rather than an asparagine residue at the penultimate position (summary by Bartuski et al., 1997 [PubMed 9268635]).[supplied by OMIM, Jan 2010]

Uniprot Description

SERPINB8: Belongs to the serpin family. Ov-serpin subfamily. 2 isoforms of the human protein are produced by alternative splicing

Protein type: Inhibitor

Chromosomal Location of Human Ortholog: 18q22.1

Cellular Component: cytosol; extracellular space

Molecular Function: protein binding; serine-type endopeptidase inhibitor activity

Disease: Peeling Skin Syndrome 5