Mouse SERPINA3 Monoclonal Antibody | anti-SERPINA3 antibody

SERPINA3 (Serpin Peptidase Inhibitor, Clade A (alpha-1 Antiproteinase, Antitrypsin), Member 3, AACT, ACT, GIG24, GIG25, MGC88254) (HRP)

Cat. Num. AAA6182073

• Gene Names: SERPINA3; ACT; AACT; GIG24; GIG25
• Applications: Immunofluorescence, Immunohistochemistry
• Purity: Purified
• Synonyms: SERPINA3; Monoclonal Antibody; SERPINA3 (Serpin Peptidase Inhibitor; Clade A (alpha-1 Antiproteinase; Antitrypsin); Member 3; AACT; ACT; GIG24; GIG25; MGC88254) (HRP); Serpin Peptidase Inhibitor; MGC88254; anti-SERPINA3 antibody

• Host: Mouse
• Clonality: Monoclonal
• Isotype: IgG2a,k
• Clone Number: 1C10
• Specificity: Recognizes SERPINA3.
• Purity/Purification: Purified
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with horseradish peroxidase (HRP).
• Sequence Length: 423

• Applicable Applications for anti-SERPINA3 antibody: Immunofluorescence (IF), Immunohistochemistry (IHC)
• Application Notes: Applications are based on unconjugated antibody.
• Immunogen: SERPINA3 (AAH03559, 25aa-423aa) full-length recombinant protein with GST tag. MW of the GST tag alone is 26kD.
• Conjugate: HRP
• Preparation and Storage: Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Note: Sodium azide is a potent inhibitor of peroxidase and should not be added to HRP conjugates. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Testing Data

(Detection limit for recombinant GST tagged SERPINA3 is approximately 3ng/ml as a capture antibody.)

Immunohistochemistry (IHC)

(Immunoperoxidase of monoclonal antibody to SERPINA3 on formalin-fixed paraffin-embedded human kidney. [antibody concentration 3 ug/ml])

Immunohistochemistry (IHC)

(Immunoperoxidase of monoclonal antibody to SERPINA3 on formalin-fixed paraffin-embedded human kidney. [antibody concentration 3 ug/ml])

Immunofluorescence (IF)

(Immunofluorescence of monoclonal antibody to SERPINA3 on HeLa cell. [antibody concentration 10 ug/ml])

Immunofluorescence (IF)

(Immunofluorescence of monoclonal antibody to SERPINA3 on HeLa cell. [antibody concentration 10 ug/ml])

Product Categories/Family for anti-SERPINA3 antibody

Antibodies; Protease Inhibitors

References

1. Whole genome RNA expression profiling of endoscopic biliary brushings provides data suitable for biomarker discovery in cholangiocarcinoma. Chapman MH, Tidswell R, Dooley JS, Sandanayake NS, Cerec V, Deheragoda M, Lee AJ, Swanton C, Andreola F, Pereira SP.J Hepatol. 2011 Dec 13.

NCBI and Uniprot Product Information

• NCBI GI #: 127795956
• NCBI GeneID: 12
• NCBI Official Full Name: Serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
• NCBI Official Synonym Full Names: serpin family A member 3
• NCBI Official Symbol: SERPINA3
• NCBI Official Synonym Symbols: ACT; AACT; GIG24; GIG25
• NCBI Protein Information: alpha-1-antichymotrypsin
• Protein Family: Alpha-1-antichymotrypsin

NCBI Description

The protein encoded by this gene is a plasma protease inhibitor and member of the serine protease inhibitor class. Polymorphisms in this protein appear to be tissue specific and influence protease targeting. Variations in this protein's sequence have been implicated in Alzheimer's disease, and deficiency of this protein has been associated with liver disease. Mutations have been identified in patients with Parkinson disease and chronic obstructive pulmonary disease. [provided by RefSeq, Jul 2008]