Goat TREX2 Polyclonal Antibody | anti-TREX2 antibody

Goat Polyclonal to Human TREX2

Cat. Num. AAA246911

• Reactivity: Human; Predicted Reactivity: Monkey (at least 90% immunogen sequence identity)
• Applications: Immunohistochemistry, ELISA
• Purity: Immunoaffinity Purified
• Synonyms: TREX2; Polyclonal Antibody; Goat Polyclonal to Human TREX2; Anti-TREX2 Antibody (Internal) IHC-plus; 3-5 exonuclease TREX2; Human TREX2; anti-TREX2 antibody

• Host: Goat
• Reactivity: Human; Predicted Reactivity: Monkey (at least 90% immunogen sequence identity)
• Clonality: Polyclonal
• Specificity: Human TREX2.
• Purity/Purification: Immunoaffinity Purified
• Form/Format: Tris-buffered saline, pH 7.3, 0.5% BSA, 0.02% sodium azide
• Concentration: 0.5 mg/ml (varies by lot)
• Sequence Length: 236

• Applicable Applications for anti-TREX2 antibody: Immunohistochemistry (IHC - Paraffin), ELISA (EIA)
• Application Notes: ELISA (1:128000), IHC-P (3.75 ug/ml); Usage: Peptide ELISA: antibody detection limit dilution 1:128000. Western blot: Preliminary experiments gave an approx 18kDa band in lysates of Jurkat, MOLT4 and U937 after 0.5 ug/ml antibody staining. Please note that currently we cannot find an explanatio...
• Target Species: Human
• Immunogen Description: Synthetic peptide C-HRSSLENPEHDES from an internal region of human TREX2 (NP_542432.2). Percent identity with other species by BLAST analysis: Human (100%), Marmoset (92%), Gibbon (85%), Monkey (85%), Mouse (85%), Rat (85%), Hamster (85%).
• Immunogen Type: Synthetic peptide
• Immunogen: TREX2 antibody was raised against synthetic peptide C-HRSSLENPEHDES from an internal region of human TREX2 (NP_542432.2). Percent identity with other species by BLAST analysis: Human (100%), Marmoset (92%), Gibbon (85%), Monkey (85%), Mouse (85%), Rat (85%), Hamster (85%), Panda (85%), Dog (85%), Horse (85%).
• Antigen Modification: Internal
• Preparation and Storage: Store at -20 degree C. Minimize freezing and thawing.

Immunohistochemistry (IHC)

(Anti-TREX2 antibody IHC of human breast. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 3.75 ug/ml.)

NCBI and Uniprot Product Information

• NCBI GI #: 6755877
• NCBI GeneID: 24102
• NCBI Accession #: NP_036037.1
• NCBI GenBank Nucleotide #: NM_011907.4
• UniProt Accession #: Q9R1A9
• Molecular Weight: 25,955 Da
• NCBI Official Full Name: three prime repair exonuclease 2
• NCBI Official Synonym Full Names: three prime repair exonuclease 2
• NCBI Official Symbol: Trex2
• NCBI Protein Information: three prime repair exonuclease 2; 3'-5' exonuclease TREX2
• UniProt Protein Name: Three prime repair exonuclease 2
• Protein Family: Three prime repair exonuclease
• UniProt Gene Name: Trex2
• UniProt Entry Name: TREX2_MOUSE

Uniprot Description

TREX2: Exonuclease with a preference for double stranded DNA with mismatched 3' termini. May play a role in DNA repair. Belongs to the exonuclease superfamily. TREX family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Deoxyribonuclease; EC 3.1.11.2; DNA repair, damage

Cellular Component: nucleus

Molecular Function: nuclease activity; protein homodimerization activity; nucleic acid binding; hydrolase activity; metal ion binding; exonuclease activity; magnesium ion binding; 3'-5'-exodeoxyribonuclease activity; exodeoxyribonuclease III activity

Biological Process: DNA repair; DNA catabolic process, exonucleolytic; DNA metabolic process; response to DNA damage stimulus