Rabbit anti-Human SCGN  Monoclonal Antibody | anti-SCGN  antibody

Rabbit anti Human SCGN  Monoclonal Antibody

Cat. Num. AAA2544360

• Gene Names: SCGN; SEGN; CALBL; SECRET; setagin; DJ501N12.8
• Reactivity: Human
• Applications: ELISA
• Synonyms: SCGN ; Monoclonal Antibody; Rabbit anti Human SCGN Monoclonal Antibody; anti-SCGN antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Monoclonal
• Isotype: IgG
• Sequence Length: 276

• Applicable Applications for anti-SCGN antibody: ELISA (EIA)
• Application Notes: ELISA: 0.1-0.2 mug/mL. This antibody can be used at 0.1-0.2 mug/mL with the appropriate secondary reagents to detect Human SCGN/Secretagogin. The detection limit for Human SCGN/Secretagogin is approximately 0.00245 ng/well.
• Immunogen: Recombinant Human SCGN/Secretagogin protein
• Buffer: 0.2 mum filtered solution in PBS with 5% trehalose
• Preparation and Storage: This antibody can be stored at 2 degree C- 8 degree C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 degree C to -80 degree C. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.

Related Product Information for anti-SCGN  antibody

Secretagogin, also known as SCGN, is a secreted protein which is detectable in human serum after ischemic neuronal damage. It is a recently described calcium-binding protein. Secretagogin/SCGN is expressed at high levels in the pancreatic islets of Langerhans and to a much lesser extent in the gastrointestinal tract (stomach, small intestine and colon), the adrenal medulla and cortex and the thyroid C-cells. In the brain, the expression of Secretagogin/SCGN is restricted to distinct subtypes of neurons with highest expression in the molecular layer of the cerebellum (stellate and basket cells), in the anterior part of the pituitary gland, in the thalamus, in the hypothalamus and in a subgroup of neocortical neurons. Secretagogin/SCGN is widely expressed in prostatic adenocarcinoma as opposed to adenocarcinomas in other organs. The function of Secretagogin/SCGN is unknown, but it has been suggested in beta-cells to influence calcium-influx and has been observed downregulated in diabetes-prone BB rat islets exposed to cytokines. Secretagogin/SCGN is involved in the calcium metabolism of tumour cells and endothelial cells in a subset of neoplasms of the brain and its coverings. Secretagogin/SCGN is also a novel marker for neuroendocrine differentiation.

NCBI and Uniprot Product Information

• NCBI GI #: 15055537
• NCBI GeneID: 10590
• NCBI GenBank Nucleotide #: NM_006998.3
• Molecular Weight: 32,040 Da
• NCBI Official Full Name: secretagogin
• NCBI Official Synonym Full Names: secretagogin, EF-hand calcium binding protein
• NCBI Official Symbol: SCGN
• NCBI Official Synonym Symbols: SEGN; CALBL; SECRET; setagin; DJ501N12.8
• NCBI Protein Information: secretagogin
• UniProt Protein Name: Secretagogin
• UniProt Gene Name: SCGN
• UniProt Synonym Gene Names: SECRET
• UniProt Entry Name: SEGN_HUMAN

NCBI Description

The encoded protein is a secreted calcium-binding protein which is found in the cytoplasm. It is related to calbindin D-28K and calretinin. This protein is thought to be involved in KCL-stimulated calcium flux and cell proliferation. [provided by RefSeq, Jul 2008]

Uniprot Description

SCGN:

Chromosomal Location of Human Ortholog: 6p22.3-p22.1

Cellular Component: cytosol; neuron projection; nucleus; synapse

Molecular Function: calcium ion binding

Biological Process: cytosolic calcium ion homeostasis