Rabbit anti-Mouse S100A6  Monoclonal Antibody | anti-S100A6  antibody

Rabbit anti Mouse S100A6  Monoclonal Antibody

Cat. Num. AAA2544520

• Gene Names: S100A6; 2A9; PRA; 5B10; CABP; CACY
• Reactivity: Mouse
• Applications: ELISA, Immunohistochemistry
• Synonyms: S100A6 ; Monoclonal Antibody; Rabbit anti Mouse S100A6 Monoclonal Antibody; anti-S100A6 antibody

• Host: Rabbit
• Reactivity: Mouse
• Clonality: Monoclonal
• Isotype: IgG
• Sequence Length: 90

• Applicable Applications for anti-S100A6 antibody: ELISA (EIA), Immunohistochemistry (IHC) Paraffin
• Application Notes: ELISA: 0.1-0.2 mug/mL. This antibody can be used at 0.1-0.2 mug/mL with the appropriate secondary reagents to detect Mouse S100A6. The detection limit for Mouse S100A6 is approximately 0.00245 ng/well.; IHC-P: 1-10 mug/mL
• Immunogen: Recombinant Mouse S100A6 protein
• Buffer: 0.2 mum filtered solution in PBS with 5% trehalose
• Preparation and Storage: This antibody can be stored at 2 degree C- 8 degree C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 degree C to -80 degree C. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.

Related Product Information for anti-S100A6  antibody

S100 protein is a family of low molecular weight protein found in vertebrates characterized by two EF-hand calcium-binding motifs. There are at least 21 different S100 proteins, and the name is derived from the fact that the protein is 100% soluble in ammonium sulfate at neutral pH. Most S100 proteins are disulfide-linked homodimer, and is normally present in cells derived from the neural crest, chondrocytes, macrophages, dendritic cells, etc. S100 proteins have been implicated in a variety of intracellular and extracellular functions. They are involved in regulation of protein phosphorylation, transcription factors, the dynamics of cytoskeleton constituents, enzyme activities, cell growth and differentiation, and the inflammatory response. S100A6 (S100 calcium binding protein A6) is a member of the S100 family of proteins, and functions in prolactin secretion, and exocytosis. Chromosomal rearrangements and altered expression of S100A6 have been implicated in melanoma.

NCBI and Uniprot Product Information

• NCBI GI #: 14290498
• NCBI GeneID: 6277
• Molecular Weight: 10,180 Da
• NCBI Official Full Name: S100A6 protein
• NCBI Official Synonym Full Names: S100 calcium binding protein A6
• NCBI Official Symbol: S100A6
• NCBI Official Synonym Symbols: 2A9; PRA; 5B10; CABP; CACY
• NCBI Protein Information: protein S100-A6
• UniProt Protein Name: Protein S100-A6
• UniProt Gene Name: S100A6
• UniProt Synonym Gene Names: CACY; PRA
• UniProt Entry Name: S10A6_HUMAN

NCBI Description

The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in stimulation of Ca2+-dependent insulin release, stimulation of prolactin secretion, and exocytosis. Chromosomal rearrangements and altered expression of this gene have been implicated in melanoma. [provided by RefSeq, Jul 2008]

Uniprot Description

S100A6: May function as calcium sensor and contribute to cellular calcium signaling (Potential). May function by interacting with other proteins and indirectly play a role in the reorganization of the actin cytoskeleton and in cell motility. Binds 2 calcium ions. Calcium binding is cooperative. Belongs to the S-100 family.

Chromosomal Location of Human Ortholog: 1q21

Cellular Component: cytoplasm; cytosol; extrinsic to internal side of plasma membrane; nuclear envelope; nucleus; perinuclear region of cytoplasm; ruffle

Molecular Function: calcium ion binding; calcium-dependent protein binding; protein binding; protein homodimerization activity; tropomyosin binding

Biological Process: signal transduction