Rabbit anti-Human S100A16 Monoclonal Antibody | anti-S100A16 antibody
Recombinant Anti-S100A16 Antibody, Rabbit Monoclonal
Gene Names
S100A16; AAG13; S100F; DT1P1A7
Reactivity
Human
Applications
ELISA
Purity
Protein A
Synonyms
S100A16; Monoclonal Antibody; Recombinant Anti-S100A16 Antibody; Rabbit Monoclonal; S100A16 Antibody; Rabbit MAb; S100 calcium binding protein A16; Anti-AAG13 Antibody; Anti-DT1P1A7 Antibody; Anti-MGC17528 Antibody; Anti-S100F Antibody; anti-S100A16 antibody
Host
Rabbit
Reactivity
Human
Clonality
Monoclonal
Isotype
Rabbit IgG
Clone Number
140
Specificity
Human S100A16
Purity/Purification
Protein A
Form/Format
Liquid; 0.2um filtered solution in PBS
Applicable Applications for anti-S100A16 antibody
ELISA (EIA)
Application Notes
ELISA: 1:5000-1:10,000
Antibody Type
Recombinant Antibody
Immunogen
Recombinant Human S100A16 protein
Conjugation
Unconjugated
Preparation
This antibody was obtained from a rabbit immunized with purified, recombinant Human S100A16 (rh S100A16).
Preparation and Storage
This antibody can be stored at 2-8 degree C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 degree C to -80 degree C. Preservative-Free. Avoid repeated freeze-thaw cycles.
Related Product Information for anti-S100A16 antibody
S100A16 is a member of S100 protein superfamily that carries calcium-binding EF-hand motifs. S100 proteins are cell-and tissue-specific and are involved in many intra-and extracellular processes through interacting with specific target proteins. S100A16 expression was found to be astrocyte-specific. The S100A16 protein was found to accumulate within nucleoli and to translocate to the cytoplasm in response to Ca(2+) stimulation. The homodimeric structure of human S100A16 in the apo state has been obtained both in the solid state and in solution, resulting in good agreement between the structures with the exception of two loop regions. The homodimeric solution structure of human S100A16 was also calculated in the calcium(II)-bound form. Differently from most S100 proteins, the conformational rearrangement upon calcium binding is minor. Immunoprecipitation analysis revealed that S100A16 could physically interact with tumor suppressor protein p53, also a known inhibitor of adipogenesis. Overexpression or RNA interference-initiated reduction of S100A16 led to the inhibition or activation of the expression of p53-responsive genes, respectively. S100A16 protein is a novel adipogenesis-promoting factor and that increased expression of S100A16 in 3T3-L1 adipocytes can have a negative impact on insulin sensitivity.
Product Categories/Family for anti-S100A16 antibody
References
Sturchler E, et al. (2006) S100A16, a novel calcium-binding protein of the EF-hand superfamily. J Biol Chem. 281(50): 38905-17.Liu Y, et al. (2011) Identification of S100A16 as a Novel Adipogenesis Promoting Factor in 3T3-L1 Cells. Endocrinology. 152(3): 903-11.Babini E, et al. (2011) Structural characterization of human S100A16, a low-affinity calcium binder. J Biol Inorg Chem. 16(2): 243-56.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
11,801 Da
NCBI Official Full Name
protein S100-A16
NCBI Official Synonym Full Names
S100 calcium binding protein A16
NCBI Official Symbol
S100A16
NCBI Official Synonym Symbols
AAG13; S100F; DT1P1A7
NCBI Protein Information
protein S100-A16; protein S100-F; aging-associated protein 13; S100 calcium-binding protein A16; aging-associated gene 13 protein
UniProt Protein Name
Protein S100-A16
Protein Family
UniProt Gene Name
S100A16
UniProt Synonym Gene Names
S100F
UniProt Entry Name
S10AG_HUMAN
Uniprot Description
S100A16: Calcium-binding protein. Binds one calcium ion per monomer. Belongs to the S-100 family.
Protein type: Nucleolus
Chromosomal Location of Human Ortholog: 1q21
Cellular Component: cytoplasm; nucleolus; plasma membrane; cytosol
Molecular Function: protein homodimerization activity; calcium ion binding
Biological Process: response to calcium ion
Research Articles on S100A16
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Product Notes
The S100A16 s100a16 (Catalog #AAA8104918) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Recombinant Anti-S100A16 Antibody, Rabbit Monoclonal reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's S100A16 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA). ELISA: 1:5000-1:10,000. Researchers should empirically determine the suitability of the S100A16 s100a16 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "S100A16, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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